Recognition of membrane-bound fusion-peptide/MPER complexes by the HIV-1 neutralizing 2F5 antibody: implications for anti-2F5 immunogenicity

The membrane proximal external region (MPER) of the fusogenic HIV-1 glycoprotein-41 harbors the epitope sequence recognized by 2F5, a broadly neutralizing antibody isolated from an infected individual. Structural mimicry of the conserved MPER 2F5 epitope constitutes a pursued goal in the field of an...

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Veröffentlicht in:	PloS one 2012-12, Vol.7 (12), p.e52740-e52740
Hauptverfasser:	Huarte, Nerea, Araujo, Aitziber, Arranz, Rocio, Lorizate, Maier, Quendler, Heribert, Kunert, Renate, Valpuesta, José M, Nieva, José L
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS vaccines Amino Acid Sequence Animals Antibodies Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - immunology Antibodies, Monoclonal - metabolism Antibodies, Neutralizing - immunology Antibodies, Neutralizing - metabolism Antigenic determinants Antigens Biochemistry Biology Biophysics Electron microscopy Epitopes Epitopes - chemistry Epitopes - immunology Epitopes - metabolism Formulations Glycoprotein gp41 Glycoproteins HIV HIV Antibodies - immunology HIV Antibodies - metabolism HIV Envelope Protein gp41 - chemistry HIV Envelope Protein gp41 - immunology HIV Envelope Protein gp41 - metabolism HIV-1 - immunology Human immunodeficiency virus Humans Immunization Immunogenicity Immunoglobulin G - chemistry Immunoglobulin G - immunology Immunoglobulin G - metabolism Immunoglobulins Infections Life sciences Liposomes Liposomes - chemistry Liposomes - immunology Macromolecular Substances - immunology Macromolecular Substances - metabolism Macromolecular Substances - ultrastructure Medicine Membrane fusion Membrane Fusion - immunology Membrane lipids Mimicry Molecular biology Molecular Sequence Data Neutralizing Peptides Peptides - chemistry Peptides - immunology Peptides - metabolism Protein Binding - immunology Rabbits Recognition Transmission electron microscopy Vaccine development Vaccines Viral infections Viruses
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