δEF1 down-regulates ER-α expression and confers tamoxifen resistance in breast cancer

Resistance to tamoxifen therapy represents a major barrier to the successful treatment of breast cancer, where a loss of or reduced ER-α level is considered a primary mechanism. Understanding how ER-α expression is regulated would provide insights into new intervention points to overcome tamoxifen r...

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Veröffentlicht in:	PloS one 2012-12, Vol.7 (12), p.e52380
Hauptverfasser:	Guo, Shaocong, Li, Yaqing, Tong, Qi, Gu, Feng, Zhu, Tianhui, Fu, Li, Yang, Shuang
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase 17β-Estradiol Biology Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - enzymology Breast Neoplasms - genetics Breast Neoplasms - pathology Cancer Down-Regulation - drug effects Down-Regulation - genetics Drug Resistance, Neoplasm - drug effects Ectopic expression Endocrine therapy Estradiol - pharmacology Estrogen Receptor alpha - genetics Estrogen Receptor alpha - metabolism Estrogen receptors Estrogens Female Gene expression Gene Expression Regulation, Neoplastic - drug effects Homeodomain Proteins - metabolism Humans Immunoglobulins Kinases MCF-7 Cells Medicine Mutagenesis NF-kappa B - metabolism NF-κB protein Phosphatidylinositol 3-Kinases - metabolism Ribonucleic acid RNA RNA-mediated interference Sensitivity Sex hormones Signal Transduction - drug effects Tamoxifen Tamoxifen - pharmacology Transcription Transcription factors Transcription Factors - metabolism Transcription, Genetic - drug effects Tumors Up-Regulation - drug effects Zinc Finger E-box-Binding Homeobox 1
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