Crystal structure of aura virus capsid protease and its complex with dioxane: new insights into capsid-glycoprotein molecular contacts

The nucleocapsid core interaction with endodomains of glycoproteins plays a critical role in the alphavirus life cycle that is essential to virus budding. Recent cryo-electron microscopy (cryo-EM) studies provide structural insights into key interactions between capsid protein (CP) and trans-membran...

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Veröffentlicht in:	PloS one 2012-12, Vol.7 (12), p.e51288-e51288
Hauptverfasser:	Aggarwal, Megha, Tapas, Satya, Preeti, Siwach, Anjul, Kumar, Pravindra, Kuhn, Richard J, Tomar, Shailly
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Alphavirus - enzymology Amino Acid Sequence Biology Biotechnology Budding Capsid protein Chymotrypsin Crystal structure Dioxane Dioxanes - chemistry Electron microscopy Encephalitis Glycoproteins Glycoproteins - chemistry Helix-loop-helix Helix-loop-helix proteins Homology Hydrophobicity Life cycle engineering Life cycles Membrane glycoproteins Membrane proteins Models, Molecular Molecular Sequence Data Mutation Nucleocapsids Peptide Hydrolases - chemistry Protease Proteases Protein Conformation Proteinase Proteins Sequence Homology, Amino Acid Structural analysis Structural models Studies Venezuelan equine encephalitis Viral proteins Viruses
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