A dual reporter mouse model of the human β-globin locus: applications and limitations

The human β-globin locus contains the β-like globin genes (i.e. fetal γ-globin and adult β-globin), which heterotetramerize with α-globin subunits to form fetal or adult hemoglobin. Thalassemia is one of the commonest inherited disorders in the world, which results in quantitative defects of the glo...

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Veröffentlicht in:	PloS one 2012-12, Vol.7 (12), p.e51272-e51272
Hauptverfasser:	Papadopoulos, Petros, Gutiérrez, Laura, van der Linden, Reinier, Kong-A-San, John, Maas, Alex, Drabek, Dubravka, Patrinos, George P, Philipsen, Sjaak, Grosveld, Frank
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta-Globins - genetics Biology Blood Cell Line Cell lines Chromatin Defects Disease Models, Animal Disorders DNA methylation Erythrocytes Erythrocytes - cytology Ethics Fetal Hemoglobin - metabolism Fetuses Fluorescence Fluorescent Dyes - pharmacology gamma-Globins - genetics Gene clusters Gene expression Genes Genes, p53 Genes, Reporter Genetic engineering Genomes Green fluorescent protein Green Fluorescent Proteins - metabolism Hemoglobin Hemoglobinopathies - genetics Hereditary diseases Humans Loci Medical research Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Models, Biological Multigene Family Proteins Rodents Screens Studies Tagging Thalassemia Transgenic animals
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