Differential expression of CD96 surface molecule represents CD8⁺ T cells with dissimilar effector function during HIV-1 infection

During HIV-1 infection, immune dysregulation and aberrant lymphocyte functions are well-established characteristics. Cell surface molecules are important for immunological functions and changes in expression can affect lymphocyte effector functions, thereby contributing to pathogenesis and disease p...

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Veröffentlicht in:	PloS one 2012-12, Vol.7 (12), p.e51696
Hauptverfasser:	Eriksson, Emily M, Keh, Chris E, Deeks, Steven G, Martin, Jeffrey N, Hecht, Frederick M, Nixon, Douglas F
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Acquired immune deficiency syndrome Adults AIDS Antigens Antigens, CD - metabolism Biology Blood & organ donations CD4 antigen CD4 Lymphocyte Count CD8 antigen CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell Differentiation - immunology Cell surface Chronic illnesses Chronic infection Cloning Control Controllers Cytotoxicity Disease Progression Down-Regulation Effector cells Fluorescence Gene Expression Regulation Hepatitis Hepatitis B HIV HIV Infections - immunology HIV Infections - metabolism HIV-1 - immunology Human immunodeficiency virus Humans Immunoglobulin G Immunology Immunoreceptor tyrosine-based inhibition motif Immunoregulation Infections Interferon Interferon-gamma - biosynthesis Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - metabolism Lipopolysaccharides Lipopolysaccharides - immunology Lymphocytes Lymphocytes T Medicine Pathogenesis Perforin Perforin - biosynthesis Receptors Studies T cell receptors Toxicity Tyrosine γ-Interferon
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