Expression of BAFF and BAFF-R in follicular lymphoma: correlation with clinicopathologic characteristics and survival outcomes
B-cell activation factor (BAFF) and BAFF-receptor (BAFF-R) play crucial roles in the viability and proliferation of malignant lymphoma cells. Limited information exists regarding expression profiles and the prognostic role of BAFF and BAFF-R in follicular lymphoma (FL). We sought to determine the ex...
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| Veröffentlicht in: | PloS one 2012-12, Vol.7 (12), p.e50936-e50936 |
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| creator | Li, Ya-Jun Jiang, Wen-Qi Rao, Hui-Lan Huang, Jia-Jia Xia, Yi Huang, Hui-Qiang Lin, Tong-Yu Xia, Zhong-Jun Li, Su Li, Zhi-Ming |
| description | B-cell activation factor (BAFF) and BAFF-receptor (BAFF-R) play crucial roles in the viability and proliferation of malignant lymphoma cells. Limited information exists regarding expression profiles and the prognostic role of BAFF and BAFF-R in follicular lymphoma (FL). We sought to determine the expression profiles of BAFF and BAFF-R in FL and to evaluate the correlation of BAFF and BAFF-R expression with clinicopathologic characteristics and outcome of FL. Correlation between expression levels of BAFF detected by immunohistochemical (IHC) and serum levels of BAFF was also evaluated.
Paraffin-embedded specimens from 115 patients were immunohistochemically examined for BAFF and BAFF-R expression. Expression levels were dichotomized into low versus high categories based on immunostaining intensity. The correlation of BAFF and BAFF-R expression with clinicopathologic characteristics and patient outcome was assessed. Serum levels of BAFF in 35 of the 115 patients with IHC data were measured by Enzyme-linked Immunosorbent assay (ELISA).
BAFF and BAFF-R were expressed in 88.7% (102/115) and 87.8% (101/115) of the cases, respectively. BAFF expression was significantly correlated with only one clinicopathologic feature: Ann Arbor stage. No significant correlation was found between expression levels of BAFF detected by IHC and serum levels of BAFF detected by ELISA. High expression of BAFF-R, but not BAFF, was significantly correlated with inferior progression-free survival (PFS; P = 0.013) and overall survival (OS; P = 0.03). High expression of BAFF-R, bulky disease, and elevated lactate dehydrogenase were correlated with inferior PFS and OS in multivariate analysis. A prognostic scoring system incorporating these 3 risk factors identified 3 distinct prognostic groups with 5-year PFS of 59.4%, 41.9%, and 10.7% and OS of 91.3%, 79.7%, and 45.8%, respectively.
Most patients with FL variably express BAFF and BAFF-R. High expression of BAFF-R, but not BAFF, may be an independent risk factor for PFS and OS in FL. |
| doi_str_mv | 10.1371/journal.pone.0050936 |
| format | Article |
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Paraffin-embedded specimens from 115 patients were immunohistochemically examined for BAFF and BAFF-R expression. Expression levels were dichotomized into low versus high categories based on immunostaining intensity. The correlation of BAFF and BAFF-R expression with clinicopathologic characteristics and patient outcome was assessed. Serum levels of BAFF in 35 of the 115 patients with IHC data were measured by Enzyme-linked Immunosorbent assay (ELISA).
BAFF and BAFF-R were expressed in 88.7% (102/115) and 87.8% (101/115) of the cases, respectively. BAFF expression was significantly correlated with only one clinicopathologic feature: Ann Arbor stage. No significant correlation was found between expression levels of BAFF detected by IHC and serum levels of BAFF detected by ELISA. High expression of BAFF-R, but not BAFF, was significantly correlated with inferior progression-free survival (PFS; P = 0.013) and overall survival (OS; P = 0.03). High expression of BAFF-R, bulky disease, and elevated lactate dehydrogenase were correlated with inferior PFS and OS in multivariate analysis. A prognostic scoring system incorporating these 3 risk factors identified 3 distinct prognostic groups with 5-year PFS of 59.4%, 41.9%, and 10.7% and OS of 91.3%, 79.7%, and 45.8%, respectively.
Most patients with FL variably express BAFF and BAFF-R. High expression of BAFF-R, but not BAFF, may be an independent risk factor for PFS and OS in FL.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0050936</identifier><identifier>PMID: 23272079</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Aged ; Analysis ; Antigens ; Apoptosis ; B-Cell Activating Factor - biosynthesis ; B-Cell Activation Factor Receptor - biosynthesis ; Biology ; BLyS protein ; Cancer ; Cell activation ; Cell Proliferation ; Cell Survival ; Classification ; Correlation ; Disease ; Disease-Free Survival ; Enzyme-linked immunosorbent assay ; Enzyme-Linked Immunosorbent Assay - methods ; Enzymes ; Ethics ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; Immunohistochemistry - methods ; L-Lactate dehydrogenase ; Laboratories ; Lactate dehydrogenase ; Lactic acid ; Lymphocytes ; Lymphocytes B ; Lymphoma ; Lymphoma, Follicular - metabolism ; Lymphomas ; Male ; Medical prognosis ; Medicine ; Middle Aged ; Models, Statistical ; Multivariate analysis ; Non-Hodgkin's lymphomas ; Oncology ; Paraffin ; Patients ; Prognosis ; Proteins ; Risk analysis ; Risk factors ; Serum levels ; Studies ; Survival ; Treatment Outcome ; Tumor necrosis factor-TNF ; Viability</subject><ispartof>PloS one, 2012-12, Vol.7 (12), p.e50936-e50936</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>2012 Li et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2012 Li et al 2012 Li et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-1ae3ed07f85f6f263a4f02dbe84084191eac933eb6346f20c6a03fcdda8f44e93</citedby><cites>FETCH-LOGICAL-c692t-1ae3ed07f85f6f263a4f02dbe84084191eac933eb6346f20c6a03fcdda8f44e93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521766/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521766/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23272079$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Navarro, Alfons</contributor><creatorcontrib>Li, Ya-Jun</creatorcontrib><creatorcontrib>Jiang, Wen-Qi</creatorcontrib><creatorcontrib>Rao, Hui-Lan</creatorcontrib><creatorcontrib>Huang, Jia-Jia</creatorcontrib><creatorcontrib>Xia, Yi</creatorcontrib><creatorcontrib>Huang, Hui-Qiang</creatorcontrib><creatorcontrib>Lin, Tong-Yu</creatorcontrib><creatorcontrib>Xia, Zhong-Jun</creatorcontrib><creatorcontrib>Li, Su</creatorcontrib><creatorcontrib>Li, Zhi-Ming</creatorcontrib><title>Expression of BAFF and BAFF-R in follicular lymphoma: correlation with clinicopathologic characteristics and survival outcomes</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>B-cell activation factor (BAFF) and BAFF-receptor (BAFF-R) play crucial roles in the viability and proliferation of malignant lymphoma cells. Limited information exists regarding expression profiles and the prognostic role of BAFF and BAFF-R in follicular lymphoma (FL). We sought to determine the expression profiles of BAFF and BAFF-R in FL and to evaluate the correlation of BAFF and BAFF-R expression with clinicopathologic characteristics and outcome of FL. Correlation between expression levels of BAFF detected by immunohistochemical (IHC) and serum levels of BAFF was also evaluated.
Paraffin-embedded specimens from 115 patients were immunohistochemically examined for BAFF and BAFF-R expression. Expression levels were dichotomized into low versus high categories based on immunostaining intensity. The correlation of BAFF and BAFF-R expression with clinicopathologic characteristics and patient outcome was assessed. Serum levels of BAFF in 35 of the 115 patients with IHC data were measured by Enzyme-linked Immunosorbent assay (ELISA).
BAFF and BAFF-R were expressed in 88.7% (102/115) and 87.8% (101/115) of the cases, respectively. BAFF expression was significantly correlated with only one clinicopathologic feature: Ann Arbor stage. No significant correlation was found between expression levels of BAFF detected by IHC and serum levels of BAFF detected by ELISA. High expression of BAFF-R, but not BAFF, was significantly correlated with inferior progression-free survival (PFS; P = 0.013) and overall survival (OS; P = 0.03). High expression of BAFF-R, bulky disease, and elevated lactate dehydrogenase were correlated with inferior PFS and OS in multivariate analysis. A prognostic scoring system incorporating these 3 risk factors identified 3 distinct prognostic groups with 5-year PFS of 59.4%, 41.9%, and 10.7% and OS of 91.3%, 79.7%, and 45.8%, respectively.
Most patients with FL variably express BAFF and BAFF-R. High expression of BAFF-R, but not BAFF, may be an independent risk factor for PFS and OS in FL.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Analysis</subject><subject>Antigens</subject><subject>Apoptosis</subject><subject>B-Cell Activating Factor - biosynthesis</subject><subject>B-Cell Activation Factor Receptor - biosynthesis</subject><subject>Biology</subject><subject>BLyS protein</subject><subject>Cancer</subject><subject>Cell activation</subject><subject>Cell Proliferation</subject><subject>Cell Survival</subject><subject>Classification</subject><subject>Correlation</subject><subject>Disease</subject><subject>Disease-Free Survival</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Enzyme-Linked Immunosorbent Assay - methods</subject><subject>Enzymes</subject><subject>Ethics</subject><subject>Female</subject><subject>Gene Expression Profiling</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Immunohistochemistry - methods</subject><subject>L-Lactate dehydrogenase</subject><subject>Laboratories</subject><subject>Lactate dehydrogenase</subject><subject>Lactic acid</subject><subject>Lymphocytes</subject><subject>Lymphocytes B</subject><subject>Lymphoma</subject><subject>Lymphoma, Follicular - metabolism</subject><subject>Lymphomas</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Models, Statistical</subject><subject>Multivariate analysis</subject><subject>Non-Hodgkin's lymphomas</subject><subject>Oncology</subject><subject>Paraffin</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Proteins</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Serum levels</subject><subject>Studies</subject><subject>Survival</subject><subject>Treatment Outcome</subject><subject>Tumor necrosis 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of BAFF and BAFF-R in follicular lymphoma: correlation with clinicopathologic characteristics and survival outcomes</title><author>Li, Ya-Jun ; Jiang, Wen-Qi ; Rao, Hui-Lan ; Huang, Jia-Jia ; Xia, Yi ; Huang, Hui-Qiang ; Lin, Tong-Yu ; Xia, Zhong-Jun ; Li, Su ; Li, Zhi-Ming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-1ae3ed07f85f6f263a4f02dbe84084191eac933eb6346f20c6a03fcdda8f44e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Analysis</topic><topic>Antigens</topic><topic>Apoptosis</topic><topic>B-Cell Activating Factor - biosynthesis</topic><topic>B-Cell Activation Factor Receptor - biosynthesis</topic><topic>Biology</topic><topic>BLyS protein</topic><topic>Cancer</topic><topic>Cell activation</topic><topic>Cell Proliferation</topic><topic>Cell 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with clinicopathologic characteristics and survival outcomes</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2012-12-13</date><risdate>2012</risdate><volume>7</volume><issue>12</issue><spage>e50936</spage><epage>e50936</epage><pages>e50936-e50936</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>B-cell activation factor (BAFF) and BAFF-receptor (BAFF-R) play crucial roles in the viability and proliferation of malignant lymphoma cells. Limited information exists regarding expression profiles and the prognostic role of BAFF and BAFF-R in follicular lymphoma (FL). We sought to determine the expression profiles of BAFF and BAFF-R in FL and to evaluate the correlation of BAFF and BAFF-R expression with clinicopathologic characteristics and outcome of FL. Correlation between expression levels of BAFF detected by immunohistochemical (IHC) and serum levels of BAFF was also evaluated.
Paraffin-embedded specimens from 115 patients were immunohistochemically examined for BAFF and BAFF-R expression. Expression levels were dichotomized into low versus high categories based on immunostaining intensity. The correlation of BAFF and BAFF-R expression with clinicopathologic characteristics and patient outcome was assessed. Serum levels of BAFF in 35 of the 115 patients with IHC data were measured by Enzyme-linked Immunosorbent assay (ELISA).
BAFF and BAFF-R were expressed in 88.7% (102/115) and 87.8% (101/115) of the cases, respectively. BAFF expression was significantly correlated with only one clinicopathologic feature: Ann Arbor stage. No significant correlation was found between expression levels of BAFF detected by IHC and serum levels of BAFF detected by ELISA. High expression of BAFF-R, but not BAFF, was significantly correlated with inferior progression-free survival (PFS; P = 0.013) and overall survival (OS; P = 0.03). High expression of BAFF-R, bulky disease, and elevated lactate dehydrogenase were correlated with inferior PFS and OS in multivariate analysis. A prognostic scoring system incorporating these 3 risk factors identified 3 distinct prognostic groups with 5-year PFS of 59.4%, 41.9%, and 10.7% and OS of 91.3%, 79.7%, and 45.8%, respectively.
Most patients with FL variably express BAFF and BAFF-R. High expression of BAFF-R, but not BAFF, may be an independent risk factor for PFS and OS in FL.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23272079</pmid><doi>10.1371/journal.pone.0050936</doi><tpages>e50936</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2012-12, Vol.7 (12), p.e50936-e50936 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1327136215 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adolescent Adult Aged Analysis Antigens Apoptosis B-Cell Activating Factor - biosynthesis B-Cell Activation Factor Receptor - biosynthesis Biology BLyS protein Cancer Cell activation Cell Proliferation Cell Survival Classification Correlation Disease Disease-Free Survival Enzyme-linked immunosorbent assay Enzyme-Linked Immunosorbent Assay - methods Enzymes Ethics Female Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans Immunohistochemistry - methods L-Lactate dehydrogenase Laboratories Lactate dehydrogenase Lactic acid Lymphocytes Lymphocytes B Lymphoma Lymphoma, Follicular - metabolism Lymphomas Male Medical prognosis Medicine Middle Aged Models, Statistical Multivariate analysis Non-Hodgkin's lymphomas Oncology Paraffin Patients Prognosis Proteins Risk analysis Risk factors Serum levels Studies Survival Treatment Outcome Tumor necrosis factor-TNF Viability |
| title | Expression of BAFF and BAFF-R in follicular lymphoma: correlation with clinicopathologic characteristics and survival outcomes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T03%3A45%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Expression%20of%20BAFF%20and%20BAFF-R%20in%20follicular%20lymphoma:%20correlation%20with%20clinicopathologic%20characteristics%20and%20survival%20outcomes&rft.jtitle=PloS%20one&rft.au=Li,%20Ya-Jun&rft.date=2012-12-13&rft.volume=7&rft.issue=12&rft.spage=e50936&rft.epage=e50936&rft.pages=e50936-e50936&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0050936&rft_dat=%3Cgale_plos_%3EA477083716%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1327136215&rft_id=info:pmid/23272079&rft_galeid=A477083716&rft_doaj_id=oai_doaj_org_article_dff8711c1faa4d80862d5b8bf61a51c1&rfr_iscdi=true |