Human regulatory T cells of G-CSF mobilized allogeneic stem cell donors qualify for clinical application

Recent clinical studies demonstrate the high potency of regulatory T cells (Tregs) to control graft-versus-host disease in hematopoietic stem cell transplantation (SCT). However, the adoptive transfer of Tregs is limited by their low frequency in unstimulated donors and considerable concerns that G-...

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Veröffentlicht in:	PloS one 2012-12, Vol.7 (12), p.e51644-e51644
Hauptverfasser:	Ukena, Sya N, Velaga, Sarvari, Goudeva, Lilia, Ivanyi, Philipp, Olek, Sven, Falk, Christine S, Ganser, Arnold, Franzke, Anke
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive transfer Adult Age Biology Bone marrow CD25 antigen CD4 antigen Cell Count Cell culture Cell Movement - drug effects Cell proliferation Cell Proliferation - drug effects Clinical Trials as Topic CXCR3 protein Cytokines Diabetes Disease control Effector cells Epigenetics Female Genotype & phenotype Graft-versus-host reaction Grafts Granulocyte colony-stimulating factor Granulocyte Colony-Stimulating Factor - pharmacology Hematology Hematopoietic Stem Cell Mobilization Hematopoietic Stem Cell Transplantation Hematopoietic stem cells Humans Immunoglobulins Immunological tolerance Immunoregulation Interleukin-2 Receptor alpha Subunit - metabolism Interleukin-7 Receptor alpha Subunit - metabolism Lymphocytes Lymphocytes T Male Medical schools Medicine Middle Aged Oncology Phenotype Stability Stem cell transplantation Stem cells T cell receptors T cells T-Lymphocytes, Regulatory - cytology T-Lymphocytes, Regulatory - drug effects Th1 Cells - cytology Th1 Cells - drug effects Th1 Cells - immunology Tissue Donors Transcription factors Transplantation Transplantation, Homologous Transplants & implants Young Adult
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