Increasing hippocampal estrogen receptor alpha levels via viral vectors increases MAP kinase activation and enhances memory in aging rats in the absence of ovarian estrogens

We previously demonstrated that aged ovariectomized rats that had received prior estradiol treatment in middle-age exhibited increased levels of estrogen receptor alpha (ERα) in the hippocampus as well as enhanced hippocampal dependent memory as compared to aged rats that had not received mid-life e...

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Veröffentlicht in:	PloS one 2012-12, Vol.7 (12), p.e51385-e51385
Hauptverfasser:	Witty, Christine F, Foster, Thomas C, Semple-Rowland, Susan L, Daniel, Jill M
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Acetyltransferase Aging Aging - genetics Aging - metabolism AKT protein Animals Biology Choline Choline O-acetyltransferase Cognition & reasoning Cognitive ability Comparative analysis Estradiol Estrogen Receptor alpha - genetics Estrogen Receptor alpha - metabolism Estrogen receptors Estrogens Extracellular signal-regulated kinase Females Genetic Vectors Gerontology Hippocampus Hippocampus - metabolism Immunological memory Kinases MAP kinase Maze Learning Medicine Memory - drug effects Memory - physiology Memory tasks Menopause Mental task performance Mitogen-Activated Protein Kinases - metabolism Ovariectomy Phenols (Class of compounds) Phosphorylation Phosphotransferases Rats Rodents Sex hormones Spatial analysis Spatial memory Viruses Western blotting
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