The mitochondria-targeted antioxidants and remote kidney preconditioning ameliorate brain damage through kidney-to-brain cross-talk

Many ischemia-induced neurological pathologies including stroke are associated with high oxidative stress. Mitochondria-targeted antioxidants could rescue the ischemic organ by providing specific delivery of antioxidant molecules to the mitochondrion, which potentially suffers from oxidative stress...

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Veröffentlicht in:	PloS one 2012-12, Vol.7 (12), p.e51553
Hauptverfasser:	Silachev, Denis N, Isaev, Nikolay K, Pevzner, Irina B, Zorova, Ljubava D, Stelmashook, Elena V, Novikova, Svetlana V, Plotnikov, Egor Y, Skulachev, Vladimir P, Zorov, Dmitry B
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoglycosides Animals Antibiotics Antioxidants Antioxidants (Nutrients) Antioxidants - metabolism Bioengineering Bioinformatics Biology Blood Brain Brain - metabolism Brain - pathology Brain damage Brain injury Brain research Cerebral infarction Compartments Cultivation Epithelial Cells - pathology Erythropoietin Erythropoietin - metabolism Gentamicin Gentamicins - pharmacology Glycogen Glycogen synthase kinase 3 Glycogen synthesis Heart attacks Hypoxia Immunoassay Infarction Infarction, Middle Cerebral Artery Injection Ischemia Ischemia - pathology Ischemic Preconditioning - methods Kidney - metabolism Kidney - pathology Kidney Tubules - pathology Kidneys Kinases Male Medicine Mitochondria Mitochondria - metabolism Models, Biological Nephrectomy Neurology Neurons Neuroprotection Oxidation-Reduction Oxidative Stress Phosphorylation Plastoquinone - analogs & derivatives Plastoquinone - pharmacology Preconditioning Rats Recovery of function Rhodamines - pharmacology Stroke Transcription factors Urine
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