Positive association between hepatitis C infection and oral cavity cancer: a nationwide population-based cohort study in Taiwan
The association between viral hepatitis (B and C) and oral cavity cancer has been widely debated. This nationwide, population-based cohort study assessed the subsequent risk of oral cavity cancer among patients with chronic viral hepatitis infection. Data were retrieved from insurance claims data of...
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| Veröffentlicht in: | PloS one 2012-10, Vol.7 (10), p.e48109-e48109 |
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| creator | Su, Fu-Hsiung Chang, Shih-Ni Chen, Pei-Chun Sung, Fung-Chang Huang, Shiang-Fu Chiou, Hung-Yi Su, Chien-Tien Lin, Cheng-Chieh Yeh, Chih-Ching |
| description | The association between viral hepatitis (B and C) and oral cavity cancer has been widely debated. This nationwide, population-based cohort study assessed the subsequent risk of oral cavity cancer among patients with chronic viral hepatitis infection.
Data were retrieved from insurance claims data of 1,000,000 randomly sampled individuals covered under the Taiwan National Health Insurance system. We identified a total of 21,199 adults with chronic viral hepatitis infection (12,369 with HBV alone, 5,311 with HCV alone, and 3,519 with HBV/HCV dual infections) from 2000-2005. Comparison group comprised 84,796 sex- and age-matched subjects without viral hepatitis during the same study period. Incidence and risk of subsequent oral cavity cancer were measured until 2008.
The incidence of oral cavity cancers was 2.28-fold higher among patients with HCV alone than non-viral hepatitis group (6.15 versus 2.69 per 10,000 person-years). After adjusting for sociodemographic covariates, HCV alone was significantly associated with an increased risk for oral cavity cancer (hazard ratio (HR) = 1.90, 95% confidence interval (CI) = 1.20-3.02). This positive association was highest among individuals in the 40-49-year age group (HR = 2.57, 95% CI = 1.21-5.46). However, there were no significant associations between HBV alone or HBV/HCV dual infections and risk for oral cavity cancer.
Our data suggest that HCV but not HBV infection is a risk factor for oral cavity cancer. In addition, subjects with HCV infection tend to be at early onset risk for oral cavity cancer. This finding needs to be replicated in further studies. |
| doi_str_mv | 10.1371/journal.pone.0048109 |
| format | Article |
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Data were retrieved from insurance claims data of 1,000,000 randomly sampled individuals covered under the Taiwan National Health Insurance system. We identified a total of 21,199 adults with chronic viral hepatitis infection (12,369 with HBV alone, 5,311 with HCV alone, and 3,519 with HBV/HCV dual infections) from 2000-2005. Comparison group comprised 84,796 sex- and age-matched subjects without viral hepatitis during the same study period. Incidence and risk of subsequent oral cavity cancer were measured until 2008.
The incidence of oral cavity cancers was 2.28-fold higher among patients with HCV alone than non-viral hepatitis group (6.15 versus 2.69 per 10,000 person-years). After adjusting for sociodemographic covariates, HCV alone was significantly associated with an increased risk for oral cavity cancer (hazard ratio (HR) = 1.90, 95% confidence interval (CI) = 1.20-3.02). This positive association was highest among individuals in the 40-49-year age group (HR = 2.57, 95% CI = 1.21-5.46). However, there were no significant associations between HBV alone or HBV/HCV dual infections and risk for oral cavity cancer.
Our data suggest that HCV but not HBV infection is a risk factor for oral cavity cancer. In addition, subjects with HCV infection tend to be at early onset risk for oral cavity cancer. This finding needs to be replicated in further studies.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0048109</identifier><identifier>PMID: 23133554</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Adults ; Aged ; Alcohol ; Ambulatory care ; Analysis ; Antigens ; Cancer ; Cancer research ; Chronic infection ; Cohort analysis ; Cohort Studies ; Comorbidity ; Confidence intervals ; Dental materials ; Epidemiology ; Female ; Health care ; Health insurance ; Health risk assessment ; Health risks ; Hepatitis ; Hepatitis B ; Hepatitis C ; Hepatitis C - complications ; Hepatitis C - diagnosis ; Hepatitis C - virology ; Hepatitis C virus ; Hospitals ; Humans ; Incidence ; Infection ; Infections ; Insurance ; Insurance Claim Review ; Liver cancer ; Lymphoma ; Male ; Medical diagnosis ; Medical research ; Medicine ; Middle Aged ; Mouth Neoplasms - complications ; Mouth Neoplasms - diagnosis ; Mouth Neoplasms - virology ; National health insurance ; Nutrition ; Oral cancer ; Oral cavity ; Patients ; Personal identification numbers ; Population studies ; Population-based studies ; Prevalence ; Preventive medicine ; Proportional Hazards Models ; Public health ; Risk Factors ; Smoking ; Studies ; Systematic review ; Taiwan ; Viruses</subject><ispartof>PloS one, 2012-10, Vol.7 (10), p.e48109-e48109</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>2012 Su et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2012 Su et al 2012 Su et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-371270347d28cf7b236bf73239e6c8c6e55854b00e56cb5522657335825443f73</citedby><cites>FETCH-LOGICAL-c692t-371270347d28cf7b236bf73239e6c8c6e55854b00e56cb5522657335825443f73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485043/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485043/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23133554$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Miao, Xiao-Ping</contributor><creatorcontrib>Su, Fu-Hsiung</creatorcontrib><creatorcontrib>Chang, Shih-Ni</creatorcontrib><creatorcontrib>Chen, Pei-Chun</creatorcontrib><creatorcontrib>Sung, Fung-Chang</creatorcontrib><creatorcontrib>Huang, Shiang-Fu</creatorcontrib><creatorcontrib>Chiou, Hung-Yi</creatorcontrib><creatorcontrib>Su, Chien-Tien</creatorcontrib><creatorcontrib>Lin, Cheng-Chieh</creatorcontrib><creatorcontrib>Yeh, Chih-Ching</creatorcontrib><title>Positive association between hepatitis C infection and oral cavity cancer: a nationwide population-based cohort study in Taiwan</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The association between viral hepatitis (B and C) and oral cavity cancer has been widely debated. This nationwide, population-based cohort study assessed the subsequent risk of oral cavity cancer among patients with chronic viral hepatitis infection.
Data were retrieved from insurance claims data of 1,000,000 randomly sampled individuals covered under the Taiwan National Health Insurance system. We identified a total of 21,199 adults with chronic viral hepatitis infection (12,369 with HBV alone, 5,311 with HCV alone, and 3,519 with HBV/HCV dual infections) from 2000-2005. Comparison group comprised 84,796 sex- and age-matched subjects without viral hepatitis during the same study period. Incidence and risk of subsequent oral cavity cancer were measured until 2008.
The incidence of oral cavity cancers was 2.28-fold higher among patients with HCV alone than non-viral hepatitis group (6.15 versus 2.69 per 10,000 person-years). After adjusting for sociodemographic covariates, HCV alone was significantly associated with an increased risk for oral cavity cancer (hazard ratio (HR) = 1.90, 95% confidence interval (CI) = 1.20-3.02). This positive association was highest among individuals in the 40-49-year age group (HR = 2.57, 95% CI = 1.21-5.46). However, there were no significant associations between HBV alone or HBV/HCV dual infections and risk for oral cavity cancer.
Our data suggest that HCV but not HBV infection is a risk factor for oral cavity cancer. In addition, subjects with HCV infection tend to be at early onset risk for oral cavity cancer. This finding needs to be replicated in further studies.</description><subject>Adult</subject><subject>Adults</subject><subject>Aged</subject><subject>Alcohol</subject><subject>Ambulatory care</subject><subject>Analysis</subject><subject>Antigens</subject><subject>Cancer</subject><subject>Cancer research</subject><subject>Chronic infection</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Comorbidity</subject><subject>Confidence intervals</subject><subject>Dental materials</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Health care</subject><subject>Health insurance</subject><subject>Health risk assessment</subject><subject>Health risks</subject><subject>Hepatitis</subject><subject>Hepatitis B</subject><subject>Hepatitis C</subject><subject>Hepatitis C - complications</subject><subject>Hepatitis C - diagnosis</subject><subject>Hepatitis C - virology</subject><subject>Hepatitis C virus</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infection</subject><subject>Infections</subject><subject>Insurance</subject><subject>Insurance Claim Review</subject><subject>Liver cancer</subject><subject>Lymphoma</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Mouth Neoplasms - complications</subject><subject>Mouth Neoplasms - diagnosis</subject><subject>Mouth Neoplasms - virology</subject><subject>National health insurance</subject><subject>Nutrition</subject><subject>Oral cancer</subject><subject>Oral cavity</subject><subject>Patients</subject><subject>Personal identification numbers</subject><subject>Population studies</subject><subject>Population-based studies</subject><subject>Prevalence</subject><subject>Preventive medicine</subject><subject>Proportional Hazards Models</subject><subject>Public health</subject><subject>Risk Factors</subject><subject>Smoking</subject><subject>Studies</subject><subject>Systematic review</subject><subject>Taiwan</subject><subject>Viruses</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk02P0zAQhiMEYpeFf4DAEhKCQ4s_44QD0qrio9JKi2DhajnOpHWVxiF2Wnrir-O22VWD9oBycDx-5rXfsSdJnhM8JUySdyvXd42up61rYIoxzwjOHyTnJGd0klLMHp78nyVPvF9hLFiWpo-TM8oIY0Lw8-TPV-dtsBtA2ntnrA7WNaiAsAVo0BLaGAjWoxmyTQXmsKqbErlO18jojQ27ODQGuvdIo-aQvrUloNa1fX2YTgrtoUTGLV0XkA99uYti6EbbrW6eJo8qXXt4NowXyY9PH29mXyZX15_ns8uriUlzGibRMJWYcVnSzFSyoCwtKskoyyE1mUlBiEzwAmMQqSmEoDQVMlrMqOCcRfIieXnUbWvn1VA7rwijkjAs8ywS8yNROr1SbWfXutspp606BFy3ULoL1tSgqoJLaUCyotA8pVJTLCtMJcSZoVUVtT4Mu_XFGkoDTYj1GomOVxq7VAu3UYxnAnMWBd4MAp371YMPam29gbrWDbg-nptwlpM0EySir_5B73c3UAsdDcS7dHFfsxdVl9EM5kQcqOk9VPxKWFsTH1plY3yU8HaUEJkAv8NC996r-fdv_89e_xyzr0_YJeg6LL2r-_178mOQH0HTOe87qO6KTLDa98ltNdS-T9TQJzHtxekF3SXdNgb7C0bGDbU</recordid><startdate>20121025</startdate><enddate>20121025</enddate><creator>Su, Fu-Hsiung</creator><creator>Chang, Shih-Ni</creator><creator>Chen, Pei-Chun</creator><creator>Sung, Fung-Chang</creator><creator>Huang, Shiang-Fu</creator><creator>Chiou, Hung-Yi</creator><creator>Su, Chien-Tien</creator><creator>Lin, Cheng-Chieh</creator><creator>Yeh, Chih-Ching</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20121025</creationdate><title>Positive association between hepatitis C infection and oral cavity cancer: a nationwide population-based cohort study in Taiwan</title><author>Su, Fu-Hsiung ; Chang, Shih-Ni ; Chen, Pei-Chun ; Sung, Fung-Chang ; Huang, Shiang-Fu ; Chiou, Hung-Yi ; Su, Chien-Tien ; Lin, Cheng-Chieh ; Yeh, Chih-Ching</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-371270347d28cf7b236bf73239e6c8c6e55854b00e56cb5522657335825443f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Adults</topic><topic>Aged</topic><topic>Alcohol</topic><topic>Ambulatory care</topic><topic>Analysis</topic><topic>Antigens</topic><topic>Cancer</topic><topic>Cancer research</topic><topic>Chronic infection</topic><topic>Cohort analysis</topic><topic>Cohort Studies</topic><topic>Comorbidity</topic><topic>Confidence intervals</topic><topic>Dental materials</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Health care</topic><topic>Health insurance</topic><topic>Health risk assessment</topic><topic>Health risks</topic><topic>Hepatitis</topic><topic>Hepatitis B</topic><topic>Hepatitis C</topic><topic>Hepatitis C - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Su, Fu-Hsiung</au><au>Chang, Shih-Ni</au><au>Chen, Pei-Chun</au><au>Sung, Fung-Chang</au><au>Huang, Shiang-Fu</au><au>Chiou, Hung-Yi</au><au>Su, Chien-Tien</au><au>Lin, Cheng-Chieh</au><au>Yeh, Chih-Ching</au><au>Miao, Xiao-Ping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Positive association between hepatitis C infection and oral cavity cancer: a nationwide population-based cohort study in Taiwan</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2012-10-25</date><risdate>2012</risdate><volume>7</volume><issue>10</issue><spage>e48109</spage><epage>e48109</epage><pages>e48109-e48109</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The association between viral hepatitis (B and C) and oral cavity cancer has been widely debated. This nationwide, population-based cohort study assessed the subsequent risk of oral cavity cancer among patients with chronic viral hepatitis infection.
Data were retrieved from insurance claims data of 1,000,000 randomly sampled individuals covered under the Taiwan National Health Insurance system. We identified a total of 21,199 adults with chronic viral hepatitis infection (12,369 with HBV alone, 5,311 with HCV alone, and 3,519 with HBV/HCV dual infections) from 2000-2005. Comparison group comprised 84,796 sex- and age-matched subjects without viral hepatitis during the same study period. Incidence and risk of subsequent oral cavity cancer were measured until 2008.
The incidence of oral cavity cancers was 2.28-fold higher among patients with HCV alone than non-viral hepatitis group (6.15 versus 2.69 per 10,000 person-years). After adjusting for sociodemographic covariates, HCV alone was significantly associated with an increased risk for oral cavity cancer (hazard ratio (HR) = 1.90, 95% confidence interval (CI) = 1.20-3.02). This positive association was highest among individuals in the 40-49-year age group (HR = 2.57, 95% CI = 1.21-5.46). However, there were no significant associations between HBV alone or HBV/HCV dual infections and risk for oral cavity cancer.
Our data suggest that HCV but not HBV infection is a risk factor for oral cavity cancer. In addition, subjects with HCV infection tend to be at early onset risk for oral cavity cancer. This finding needs to be replicated in further studies.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23133554</pmid><doi>10.1371/journal.pone.0048109</doi><tpages>e48109</tpages><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_1327130798 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Adult Adults Aged Alcohol Ambulatory care Analysis Antigens Cancer Cancer research Chronic infection Cohort analysis Cohort Studies Comorbidity Confidence intervals Dental materials Epidemiology Female Health care Health insurance Health risk assessment Health risks Hepatitis Hepatitis B Hepatitis C Hepatitis C - complications Hepatitis C - diagnosis Hepatitis C - virology Hepatitis C virus Hospitals Humans Incidence Infection Infections Insurance Insurance Claim Review Liver cancer Lymphoma Male Medical diagnosis Medical research Medicine Middle Aged Mouth Neoplasms - complications Mouth Neoplasms - diagnosis Mouth Neoplasms - virology National health insurance Nutrition Oral cancer Oral cavity Patients Personal identification numbers Population studies Population-based studies Prevalence Preventive medicine Proportional Hazards Models Public health Risk Factors Smoking Studies Systematic review Taiwan Viruses |
| title | Positive association between hepatitis C infection and oral cavity cancer: a nationwide population-based cohort study in Taiwan |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T06%3A51%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Positive%20association%20between%20hepatitis%20C%20infection%20and%20oral%20cavity%20cancer:%20a%20nationwide%20population-based%20cohort%20study%20in%20Taiwan&rft.jtitle=PloS%20one&rft.au=Su,%20Fu-Hsiung&rft.date=2012-10-25&rft.volume=7&rft.issue=10&rft.spage=e48109&rft.epage=e48109&rft.pages=e48109-e48109&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0048109&rft_dat=%3Cgale_plos_%3EA477041598%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1327130798&rft_id=info:pmid/23133554&rft_galeid=A477041598&rft_doaj_id=oai_doaj_org_article_fb477ce73bba4627a207f027ea46c2ff&rfr_iscdi=true |