Non-invasive evaluation of cystic fibrosis related liver disease in adults with ARFI, transient elastography and different fibrosis scores
Cystic fibrosis-related liver disease (CFLD) is present in up to 30% of cystic fibrosis patients and can result in progressive liver failure. Diagnosis of CFLD is challenging. Non-invasive methods for staging of liver fibrosis display an interesting diagnostic approach for CFLD detection. We evaluat...
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| Veröffentlicht in: | PloS one 2012-07, Vol.7 (7), p.e42139 |
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| creator | Karlas, Thomas Neuschulz, Marie Oltmanns, Annett Güttler, Andrea Petroff, David Wirtz, Hubert Mainz, Jochen G Mössner, Joachim Berg, Thomas Tröltzsch, Michael Keim, Volker Wiegand, Johannes |
| description | Cystic fibrosis-related liver disease (CFLD) is present in up to 30% of cystic fibrosis patients and can result in progressive liver failure. Diagnosis of CFLD is challenging. Non-invasive methods for staging of liver fibrosis display an interesting diagnostic approach for CFLD detection.
We evaluated transient elastography (TE), acoustic radiation force impulse imaging (ARFI), and fibrosis indices for CFLD detection.
TE and ARFI were performed in 55 adult CF patients. In addition, AST/Platelets-Ratio-Index (APRI), and Forns' score were calculated. Healthy probands and patients with alcoholic liver cirrhosis served as controls.
Fourteen CF patients met CFLD criteria, six had liver cirrhosis. Elastography acquisition was successful in >89% of cases. Non-cirrhotic CFLD individuals showed elastography values similar to CF patients without liver involvement. Cases with liver cirrhosis differed significantly from other CFLD patients (ARFI: 1.49 vs. 1.13 m/s; p = 0.031; TE: 7.95 vs. 4.16 kPa; p = 0.020) and had significantly lower results than individuals with alcoholic liver cirrhosis (ARFI: 1.49 vs. 2.99 m/s; p = 0.002). APRI showed the best diagnostic performance for CFLD detection (AUROC 0.815; sensitivity 85.7%, specificity 70.7%).
ARFI, TE, and laboratory based fibrosis indices correlate with each other and reliably detect CFLD related liver cirrhosis in adult CF patients. CF specific cut-off values for cirrhosis in adults are lower than in alcoholic cirrhosis. |
| doi_str_mv | 10.1371/journal.pone.0042139 |
| format | Article |
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We evaluated transient elastography (TE), acoustic radiation force impulse imaging (ARFI), and fibrosis indices for CFLD detection.
TE and ARFI were performed in 55 adult CF patients. In addition, AST/Platelets-Ratio-Index (APRI), and Forns' score were calculated. Healthy probands and patients with alcoholic liver cirrhosis served as controls.
Fourteen CF patients met CFLD criteria, six had liver cirrhosis. Elastography acquisition was successful in >89% of cases. Non-cirrhotic CFLD individuals showed elastography values similar to CF patients without liver involvement. Cases with liver cirrhosis differed significantly from other CFLD patients (ARFI: 1.49 vs. 1.13 m/s; p = 0.031; TE: 7.95 vs. 4.16 kPa; p = 0.020) and had significantly lower results than individuals with alcoholic liver cirrhosis (ARFI: 1.49 vs. 2.99 m/s; p = 0.002). APRI showed the best diagnostic performance for CFLD detection (AUROC 0.815; sensitivity 85.7%, specificity 70.7%).
ARFI, TE, and laboratory based fibrosis indices correlate with each other and reliably detect CFLD related liver cirrhosis in adult CF patients. CF specific cut-off values for cirrhosis in adults are lower than in alcoholic cirrhosis.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0042139</identifier><identifier>PMID: 22848732</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acoustics ; Adult ; Adults ; Biology ; Biopsy ; Blood tests ; Cirrhosis ; Cohort Studies ; Cystic fibrosis ; Cystic Fibrosis - complications ; Cystic Fibrosis - diagnostic imaging ; Cystic Fibrosis - pathology ; Cysts ; Dermatology ; Diagnostic systems ; Elasticity Imaging Techniques - methods ; Female ; Fibrosis ; Gastroenterology ; Hepatitis ; Hepatology ; Hospitals ; Humans ; Hypertension ; Interdisciplinary aspects ; Internal medicine ; Liver ; Liver cirrhosis ; Liver Cirrhosis, Alcoholic - complications ; Liver diseases ; Male ; Medicine ; Neurology ; Patients ; Pediatrics ; Platelets ; Radiation ; Rheumatology ; Sound waves ; Ultrasonic imaging</subject><ispartof>PloS one, 2012-07, Vol.7 (7), p.e42139</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>Karlas et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2012 Karlas et al 2012 Karlas et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-d3890f88dbedc0e0e8d3abb1f5634c02d92903cf0c3f59dcbd135d14466768483</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405060/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405060/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,2915,23847,27905,27906,53772,53774,79349,79350</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22848732$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Hartl, Dominik</contributor><creatorcontrib>Karlas, Thomas</creatorcontrib><creatorcontrib>Neuschulz, Marie</creatorcontrib><creatorcontrib>Oltmanns, Annett</creatorcontrib><creatorcontrib>Güttler, Andrea</creatorcontrib><creatorcontrib>Petroff, David</creatorcontrib><creatorcontrib>Wirtz, Hubert</creatorcontrib><creatorcontrib>Mainz, Jochen G</creatorcontrib><creatorcontrib>Mössner, Joachim</creatorcontrib><creatorcontrib>Berg, Thomas</creatorcontrib><creatorcontrib>Tröltzsch, Michael</creatorcontrib><creatorcontrib>Keim, Volker</creatorcontrib><creatorcontrib>Wiegand, Johannes</creatorcontrib><title>Non-invasive evaluation of cystic fibrosis related liver disease in adults with ARFI, transient elastography and different fibrosis scores</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Cystic fibrosis-related liver disease (CFLD) is present in up to 30% of cystic fibrosis patients and can result in progressive liver failure. Diagnosis of CFLD is challenging. Non-invasive methods for staging of liver fibrosis display an interesting diagnostic approach for CFLD detection.
We evaluated transient elastography (TE), acoustic radiation force impulse imaging (ARFI), and fibrosis indices for CFLD detection.
TE and ARFI were performed in 55 adult CF patients. In addition, AST/Platelets-Ratio-Index (APRI), and Forns' score were calculated. Healthy probands and patients with alcoholic liver cirrhosis served as controls.
Fourteen CF patients met CFLD criteria, six had liver cirrhosis. Elastography acquisition was successful in >89% of cases. Non-cirrhotic CFLD individuals showed elastography values similar to CF patients without liver involvement. Cases with liver cirrhosis differed significantly from other CFLD patients (ARFI: 1.49 vs. 1.13 m/s; p = 0.031; TE: 7.95 vs. 4.16 kPa; p = 0.020) and had significantly lower results than individuals with alcoholic liver cirrhosis (ARFI: 1.49 vs. 2.99 m/s; p = 0.002). APRI showed the best diagnostic performance for CFLD detection (AUROC 0.815; sensitivity 85.7%, specificity 70.7%).
ARFI, TE, and laboratory based fibrosis indices correlate with each other and reliably detect CFLD related liver cirrhosis in adult CF patients. CF specific cut-off values for cirrhosis in adults are lower than in alcoholic cirrhosis.</description><subject>Acoustics</subject><subject>Adult</subject><subject>Adults</subject><subject>Biology</subject><subject>Biopsy</subject><subject>Blood tests</subject><subject>Cirrhosis</subject><subject>Cohort Studies</subject><subject>Cystic fibrosis</subject><subject>Cystic Fibrosis - complications</subject><subject>Cystic Fibrosis - diagnostic imaging</subject><subject>Cystic Fibrosis - pathology</subject><subject>Cysts</subject><subject>Dermatology</subject><subject>Diagnostic systems</subject><subject>Elasticity Imaging Techniques - methods</subject><subject>Female</subject><subject>Fibrosis</subject><subject>Gastroenterology</subject><subject>Hepatitis</subject><subject>Hepatology</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Interdisciplinary aspects</subject><subject>Internal medicine</subject><subject>Liver</subject><subject>Liver cirrhosis</subject><subject>Liver Cirrhosis, Alcoholic - 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Diagnosis of CFLD is challenging. Non-invasive methods for staging of liver fibrosis display an interesting diagnostic approach for CFLD detection.
We evaluated transient elastography (TE), acoustic radiation force impulse imaging (ARFI), and fibrosis indices for CFLD detection.
TE and ARFI were performed in 55 adult CF patients. In addition, AST/Platelets-Ratio-Index (APRI), and Forns' score were calculated. Healthy probands and patients with alcoholic liver cirrhosis served as controls.
Fourteen CF patients met CFLD criteria, six had liver cirrhosis. Elastography acquisition was successful in >89% of cases. Non-cirrhotic CFLD individuals showed elastography values similar to CF patients without liver involvement. Cases with liver cirrhosis differed significantly from other CFLD patients (ARFI: 1.49 vs. 1.13 m/s; p = 0.031; TE: 7.95 vs. 4.16 kPa; p = 0.020) and had significantly lower results than individuals with alcoholic liver cirrhosis (ARFI: 1.49 vs. 2.99 m/s; p = 0.002). APRI showed the best diagnostic performance for CFLD detection (AUROC 0.815; sensitivity 85.7%, specificity 70.7%).
ARFI, TE, and laboratory based fibrosis indices correlate with each other and reliably detect CFLD related liver cirrhosis in adult CF patients. CF specific cut-off values for cirrhosis in adults are lower than in alcoholic cirrhosis.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>22848732</pmid><doi>10.1371/journal.pone.0042139</doi><tpages>e42139</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2012-07, Vol.7 (7), p.e42139 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1327117285 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Acoustics Adult Adults Biology Biopsy Blood tests Cirrhosis Cohort Studies Cystic fibrosis Cystic Fibrosis - complications Cystic Fibrosis - diagnostic imaging Cystic Fibrosis - pathology Cysts Dermatology Diagnostic systems Elasticity Imaging Techniques - methods Female Fibrosis Gastroenterology Hepatitis Hepatology Hospitals Humans Hypertension Interdisciplinary aspects Internal medicine Liver Liver cirrhosis Liver Cirrhosis, Alcoholic - complications Liver diseases Male Medicine Neurology Patients Pediatrics Platelets Radiation Rheumatology Sound waves Ultrasonic imaging |
| title | Non-invasive evaluation of cystic fibrosis related liver disease in adults with ARFI, transient elastography and different fibrosis scores |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T13%3A23%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Non-invasive%20evaluation%20of%20cystic%20fibrosis%20related%20liver%20disease%20in%20adults%20with%20ARFI,%20transient%20elastography%20and%20different%20fibrosis%20scores&rft.jtitle=PloS%20one&rft.au=Karlas,%20Thomas&rft.date=2012-07-25&rft.volume=7&rft.issue=7&rft.spage=e42139&rft.pages=e42139-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0042139&rft_dat=%3Cgale_plos_%3EA498251939%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1327117285&rft_id=info:pmid/22848732&rft_galeid=A498251939&rft_doaj_id=oai_doaj_org_article_9beb11ea5e11411a9394a10d90af83a9&rfr_iscdi=true |