Age-related differences in test-retest reliability in resting-state brain functional connectivity
Resting-state functional MRI (rs-fMRI) has emerged as a powerful tool for investigating brain functional connectivity (FC). Research in recent years has focused on assessing the reliability of FC across younger subjects within and between scan-sessions. Test-retest reliability in resting-state funct...
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| creator | Song, Jie Desphande, Alok S Meier, Timothy B Tudorascu, Dana L Vergun, Svyatoslav Nair, Veena A Biswal, Bharat B Meyerand, Mary E Birn, Rasmus M Bellec, Pierre Prabhakaran, Vivek |
| description | Resting-state functional MRI (rs-fMRI) has emerged as a powerful tool for investigating brain functional connectivity (FC). Research in recent years has focused on assessing the reliability of FC across younger subjects within and between scan-sessions. Test-retest reliability in resting-state functional connectivity (RSFC) has not yet been examined in older adults. In this study, we investigated age-related differences in reliability and stability of RSFC across scans. In addition, we examined how global signal regression (GSR) affects RSFC reliability and stability. Three separate resting-state scans from 29 younger adults (18-35 yrs) and 26 older adults (55-85 yrs) were obtained from the International Consortium for Brain Mapping (ICBM) dataset made publically available as part of the 1000 Functional Connectomes project www.nitrc.org/projects/fcon_1000. 92 regions of interest (ROIs) with 5 cubic mm radius, derived from the default, cingulo-opercular, fronto-parietal and sensorimotor networks, were previously defined based on a recent study. Mean time series were extracted from each of the 92 ROIs from each scan and three matrices of z-transformed correlation coefficients were created for each subject, which were then used for evaluation of multi-scan reliability and stability. The young group showed higher reliability of RSFC than the old group with GSR (p-value = 0.028) and without GSR (p-value |
| doi_str_mv | 10.1371/journal.pone.0049847 |
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Research in recent years has focused on assessing the reliability of FC across younger subjects within and between scan-sessions. Test-retest reliability in resting-state functional connectivity (RSFC) has not yet been examined in older adults. In this study, we investigated age-related differences in reliability and stability of RSFC across scans. In addition, we examined how global signal regression (GSR) affects RSFC reliability and stability. Three separate resting-state scans from 29 younger adults (18-35 yrs) and 26 older adults (55-85 yrs) were obtained from the International Consortium for Brain Mapping (ICBM) dataset made publically available as part of the 1000 Functional Connectomes project www.nitrc.org/projects/fcon_1000. 92 regions of interest (ROIs) with 5 cubic mm radius, derived from the default, cingulo-opercular, fronto-parietal and sensorimotor networks, were previously defined based on a recent study. Mean time series were extracted from each of the 92 ROIs from each scan and three matrices of z-transformed correlation coefficients were created for each subject, which were then used for evaluation of multi-scan reliability and stability. The young group showed higher reliability of RSFC than the old group with GSR (p-value = 0.028) and without GSR (p-value <0.001). Both groups showed a high degree of multi-scan stability of RSFC and no significant differences were found between groups. By comparing the test-retest reliability of RSFC with and without GSR across scans, we found significantly higher proportion of reliable connections in both groups without GSR, but decreased stability. Our results suggest that aging is associated with reduced reliability of RSFC which itself is highly stable within-subject across scans for both groups, and that GSR reduces the overall reliability but increases the stability in both age groups and could potentially alter group differences of RSFC.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0049847</identifier><identifier>PMID: 23227153</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Adults ; Age ; Aged ; Aged, 80 and over ; Aging ; Biology ; Biomedical engineering ; Brain ; Brain - physiology ; Brain mapping ; Connectivity ; Consortia ; Correlation coefficient ; Correlation coefficients ; Functional magnetic resonance imaging ; Health physics ; Humans ; Mathematics ; Medicine ; Middle Aged ; Neural networks ; Neurosciences ; NMR ; Nuclear magnetic resonance ; Older people ; Reliability analysis ; Reproducibility of Results ; Sensorimotor system ; Stability analysis ; Studies ; Young Adult ; Young adults</subject><ispartof>PloS one, 2012-12, Vol.7 (12), p.e49847-e49847</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>2012 Song et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2012 Song et al 2012 Song et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-87ac3e664f60fd3d3a89f1f6140d769be37662d57d01fff890145a73d7437c4f3</citedby><cites>FETCH-LOGICAL-c692t-87ac3e664f60fd3d3a89f1f6140d769be37662d57d01fff890145a73d7437c4f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515585/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515585/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23227153$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Song, Jie</creatorcontrib><creatorcontrib>Desphande, Alok S</creatorcontrib><creatorcontrib>Meier, Timothy B</creatorcontrib><creatorcontrib>Tudorascu, Dana L</creatorcontrib><creatorcontrib>Vergun, Svyatoslav</creatorcontrib><creatorcontrib>Nair, Veena A</creatorcontrib><creatorcontrib>Biswal, Bharat B</creatorcontrib><creatorcontrib>Meyerand, Mary E</creatorcontrib><creatorcontrib>Birn, Rasmus M</creatorcontrib><creatorcontrib>Bellec, Pierre</creatorcontrib><creatorcontrib>Prabhakaran, Vivek</creatorcontrib><title>Age-related differences in test-retest reliability in resting-state brain functional connectivity</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Resting-state functional MRI (rs-fMRI) has emerged as a powerful tool for investigating brain functional connectivity (FC). Research in recent years has focused on assessing the reliability of FC across younger subjects within and between scan-sessions. Test-retest reliability in resting-state functional connectivity (RSFC) has not yet been examined in older adults. In this study, we investigated age-related differences in reliability and stability of RSFC across scans. In addition, we examined how global signal regression (GSR) affects RSFC reliability and stability. Three separate resting-state scans from 29 younger adults (18-35 yrs) and 26 older adults (55-85 yrs) were obtained from the International Consortium for Brain Mapping (ICBM) dataset made publically available as part of the 1000 Functional Connectomes project www.nitrc.org/projects/fcon_1000. 92 regions of interest (ROIs) with 5 cubic mm radius, derived from the default, cingulo-opercular, fronto-parietal and sensorimotor networks, were previously defined based on a recent study. Mean time series were extracted from each of the 92 ROIs from each scan and three matrices of z-transformed correlation coefficients were created for each subject, which were then used for evaluation of multi-scan reliability and stability. The young group showed higher reliability of RSFC than the old group with GSR (p-value = 0.028) and without GSR (p-value <0.001). Both groups showed a high degree of multi-scan stability of RSFC and no significant differences were found between groups. By comparing the test-retest reliability of RSFC with and without GSR across scans, we found significantly higher proportion of reliable connections in both groups without GSR, but decreased stability. Our results suggest that aging is associated with reduced reliability of RSFC which itself is highly stable within-subject across scans for both groups, and that GSR reduces the overall reliability but increases the stability in both age groups and could potentially alter group differences of RSFC.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Adults</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Biology</subject><subject>Biomedical engineering</subject><subject>Brain</subject><subject>Brain - physiology</subject><subject>Brain mapping</subject><subject>Connectivity</subject><subject>Consortia</subject><subject>Correlation coefficient</subject><subject>Correlation coefficients</subject><subject>Functional magnetic resonance imaging</subject><subject>Health physics</subject><subject>Humans</subject><subject>Mathematics</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Neural networks</subject><subject>Neurosciences</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Older people</subject><subject>Reliability analysis</subject><subject>Reproducibility of Results</subject><subject>Sensorimotor system</subject><subject>Stability analysis</subject><subject>Studies</subject><subject>Young Adult</subject><subject>Young 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Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Song, Jie</au><au>Desphande, Alok S</au><au>Meier, Timothy B</au><au>Tudorascu, Dana L</au><au>Vergun, Svyatoslav</au><au>Nair, Veena A</au><au>Biswal, Bharat B</au><au>Meyerand, Mary E</au><au>Birn, Rasmus M</au><au>Bellec, Pierre</au><au>Prabhakaran, Vivek</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age-related differences in test-retest reliability in resting-state brain functional connectivity</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2012-12-05</date><risdate>2012</risdate><volume>7</volume><issue>12</issue><spage>e49847</spage><epage>e49847</epage><pages>e49847-e49847</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Resting-state functional MRI (rs-fMRI) has emerged as a powerful tool for investigating brain functional connectivity (FC). Research in recent years has focused on assessing the reliability of FC across younger subjects within and between scan-sessions. Test-retest reliability in resting-state functional connectivity (RSFC) has not yet been examined in older adults. In this study, we investigated age-related differences in reliability and stability of RSFC across scans. In addition, we examined how global signal regression (GSR) affects RSFC reliability and stability. Three separate resting-state scans from 29 younger adults (18-35 yrs) and 26 older adults (55-85 yrs) were obtained from the International Consortium for Brain Mapping (ICBM) dataset made publically available as part of the 1000 Functional Connectomes project www.nitrc.org/projects/fcon_1000. 92 regions of interest (ROIs) with 5 cubic mm radius, derived from the default, cingulo-opercular, fronto-parietal and sensorimotor networks, were previously defined based on a recent study. Mean time series were extracted from each of the 92 ROIs from each scan and three matrices of z-transformed correlation coefficients were created for each subject, which were then used for evaluation of multi-scan reliability and stability. The young group showed higher reliability of RSFC than the old group with GSR (p-value = 0.028) and without GSR (p-value <0.001). Both groups showed a high degree of multi-scan stability of RSFC and no significant differences were found between groups. By comparing the test-retest reliability of RSFC with and without GSR across scans, we found significantly higher proportion of reliable connections in both groups without GSR, but decreased stability. Our results suggest that aging is associated with reduced reliability of RSFC which itself is highly stable within-subject across scans for both groups, and that GSR reduces the overall reliability but increases the stability in both age groups and could potentially alter group differences of RSFC.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23227153</pmid><doi>10.1371/journal.pone.0049847</doi><tpages>e49847</tpages><oa>free_for_read</oa></addata></record> |
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| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adolescent Adult Adults Age Aged Aged, 80 and over Aging Biology Biomedical engineering Brain Brain - physiology Brain mapping Connectivity Consortia Correlation coefficient Correlation coefficients Functional magnetic resonance imaging Health physics Humans Mathematics Medicine Middle Aged Neural networks Neurosciences NMR Nuclear magnetic resonance Older people Reliability analysis Reproducibility of Results Sensorimotor system Stability analysis Studies Young Adult Young adults |
| title | Age-related differences in test-retest reliability in resting-state brain functional connectivity |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T01%3A04%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Age-related%20differences%20in%20test-retest%20reliability%20in%20resting-state%20brain%20functional%20connectivity&rft.jtitle=PloS%20one&rft.au=Song,%20Jie&rft.date=2012-12-05&rft.volume=7&rft.issue=12&rft.spage=e49847&rft.epage=e49847&rft.pages=e49847-e49847&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0049847&rft_dat=%3Cgale_plos_%3EA477090334%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1326751717&rft_id=info:pmid/23227153&rft_galeid=A477090334&rft_doaj_id=oai_doaj_org_article_f55ddc2b18f14d9d896568857c5635e5&rfr_iscdi=true |