Cognitive processing speed in older adults: relationship with white matter integrity
Cognitive processing slows with age. We sought to determine the importance of white matter integrity, assessed by diffusion tensor imaging (DTI), at influencing cognitive processing speed among normal older adults, assessed using a novel battery of computerized, non-verbal, choice reaction time task...
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| creator | Kerchner, Geoffrey A Racine, Caroline A Hale, Sandra Wilheim, Reva Laluz, Victor Miller, Bruce L Kramer, Joel H |
| description | Cognitive processing slows with age. We sought to determine the importance of white matter integrity, assessed by diffusion tensor imaging (DTI), at influencing cognitive processing speed among normal older adults, assessed using a novel battery of computerized, non-verbal, choice reaction time tasks. We studied 131 cognitively normal adults aged 55-87 using a cross-sectional design. Each participant underwent our test battery, as well as MRI with DTI. We carried out cross-subject comparisons using tract-based spatial statistics. As expected, reaction time slowed significantly with age. In diffuse areas of frontal and parietal white matter, especially the anterior corpus callosum, fractional anisotropy values correlated negatively with reaction time. The genu and body of the corpus callosum, superior longitudinal fasciculus, and inferior fronto-occipital fasciculus were among the areas most involved. This relationship was not explained by gray or white matter atrophy or by white matter lesion volume. In a statistical mediation analysis, loss of white matter integrity mediated the relationship between age and cognitive processing speed. |
| doi_str_mv | 10.1371/journal.pone.0050425 |
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We sought to determine the importance of white matter integrity, assessed by diffusion tensor imaging (DTI), at influencing cognitive processing speed among normal older adults, assessed using a novel battery of computerized, non-verbal, choice reaction time tasks. We studied 131 cognitively normal adults aged 55-87 using a cross-sectional design. Each participant underwent our test battery, as well as MRI with DTI. We carried out cross-subject comparisons using tract-based spatial statistics. As expected, reaction time slowed significantly with age. In diffuse areas of frontal and parietal white matter, especially the anterior corpus callosum, fractional anisotropy values correlated negatively with reaction time. The genu and body of the corpus callosum, superior longitudinal fasciculus, and inferior fronto-occipital fasciculus were among the areas most involved. This relationship was not explained by gray or white matter atrophy or by white matter lesion volume. 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We sought to determine the importance of white matter integrity, assessed by diffusion tensor imaging (DTI), at influencing cognitive processing speed among normal older adults, assessed using a novel battery of computerized, non-verbal, choice reaction time tasks. We studied 131 cognitively normal adults aged 55-87 using a cross-sectional design. Each participant underwent our test battery, as well as MRI with DTI. We carried out cross-subject comparisons using tract-based spatial statistics. As expected, reaction time slowed significantly with age. In diffuse areas of frontal and parietal white matter, especially the anterior corpus callosum, fractional anisotropy values correlated negatively with reaction time. The genu and body of the corpus callosum, superior longitudinal fasciculus, and inferior fronto-occipital fasciculus were among the areas most involved. This relationship was not explained by gray or white matter atrophy or by white matter lesion volume. In a statistical mediation analysis, loss of white matter integrity mediated the relationship between age and cognitive processing speed.</description><subject>Adults</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Anisotropy</subject><subject>Atrophy</subject><subject>Biology</subject><subject>Brain Mapping</subject><subject>Brain research</subject><subject>Choice Behavior</subject><subject>Cognition & reasoning</subject><subject>Cognition - physiology</subject><subject>Cognitive ability</subject><subject>Cognitive tasks</subject><subject>Corpus callosum</subject><subject>Corpus Callosum - anatomy & histology</subject><subject>Corpus Callosum - physiology</subject><subject>Cross-Sectional Studies</subject><subject>Dementia</subject><subject>Diffusion rate</subject><subject>Diffusion Tensor Imaging</subject><subject>Drug abuse</subject><subject>Female</subject><subject>Frontal Lobe - anatomy & histology</subject><subject>Frontal Lobe - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kerchner, Geoffrey A</au><au>Racine, Caroline A</au><au>Hale, Sandra</au><au>Wilheim, Reva</au><au>Laluz, Victor</au><au>Miller, Bruce L</au><au>Kramer, Joel H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cognitive processing speed in older adults: relationship with white matter integrity</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2012-11-21</date><risdate>2012</risdate><volume>7</volume><issue>11</issue><spage>e50425</spage><epage>e50425</epage><pages>e50425-e50425</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Cognitive processing slows with age. We sought to determine the importance of white matter integrity, assessed by diffusion tensor imaging (DTI), at influencing cognitive processing speed among normal older adults, assessed using a novel battery of computerized, non-verbal, choice reaction time tasks. We studied 131 cognitively normal adults aged 55-87 using a cross-sectional design. Each participant underwent our test battery, as well as MRI with DTI. We carried out cross-subject comparisons using tract-based spatial statistics. As expected, reaction time slowed significantly with age. In diffuse areas of frontal and parietal white matter, especially the anterior corpus callosum, fractional anisotropy values correlated negatively with reaction time. The genu and body of the corpus callosum, superior longitudinal fasciculus, and inferior fronto-occipital fasciculus were among the areas most involved. This relationship was not explained by gray or white matter atrophy or by white matter lesion volume. In a statistical mediation analysis, loss of white matter integrity mediated the relationship between age and cognitive processing speed.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23185621</pmid><doi>10.1371/journal.pone.0050425</doi><tpages>e50425</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adults Age Aged Aged, 80 and over Aging Anisotropy Atrophy Biology Brain Mapping Brain research Choice Behavior Cognition & reasoning Cognition - physiology Cognitive ability Cognitive tasks Corpus callosum Corpus Callosum - anatomy & histology Corpus Callosum - physiology Cross-Sectional Studies Dementia Diffusion rate Diffusion Tensor Imaging Drug abuse Female Frontal Lobe - anatomy & histology Frontal Lobe - physiology Humans Information processing Integrity Ischemia Magnetic resonance imaging Male Mediation Medicine Memory Middle Aged Neurology Neuropsychology Older people Parietal Lobe - anatomy & histology Parietal Lobe - physiology Perforant Pathway - anatomy & histology Perforant Pathway - physiology Reaction time Reaction Time - physiology Reaction time task Skin cancer Statistical analysis Substantia alba Task Performance and Analysis |
| title | Cognitive processing speed in older adults: relationship with white matter integrity |
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