Interactive association of five candidate polymorphisms in Apelin/APJ pathway with coronary artery disease among Chinese hypertensive patients

Via sequencing the genes of apelin/angiotensin receptor-like 1 (apelin/APJ) pathway, we have recently identified and validated four common polymorphisms (rs3761581, rs56204867, rs7119375, and rs10501367) implicated in the development of hypertension. Extending these findings, we, in Chinese hyperten...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2012-12, Vol.7 (12), p.e51123-e51123
Hauptverfasser:	Jin, Wei, Su, Xiuxiu, Xu, Min, Liu, Yan, Shi, Jingyi, Lu, Lin, Niu, Wenquan
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Angiotensin Apelin Apelin Receptors Asian Continental Ancestry Group - genetics Binding sites Biology Biomarkers - metabolism Cardiology Cardiovascular disease Case-Control Studies China Cholesterol Coronary artery Coronary artery disease Coronary Artery Disease - complications Coronary Artery Disease - genetics Coronary heart disease Coronary vessels Data processing Defects Development and progression Epistasis, Genetic Fasting Female Females Gender Gene frequency Gene Frequency - genetics Gene sequencing Genes Genetic aspects Genetic Association Studies Genetic Loci - genetics Genetic Predisposition to Disease Genome, Human - genetics Genomes Genomics Genotypes Haplotypes Haplotypes - genetics Health risks Heart diseases Hospitals Humans Hypertension Hypertension - complications Hypertension - genetics Hypotheses Hypothesis testing Intercellular Signaling Peptides and Proteins - genetics Laboratories Ligands Male Males Medical imaging Medical research Medicine Middle Aged Multifactor Dimensionality Reduction Patients Polymorphism, Single Nucleotide - genetics Receptors, G-Protein-Coupled - genetics Regression analysis Regression models Signal Transduction - genetics Studies Type 2 diabetes
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!