Inhibition of angiotensin-converting enzyme activity by flavonoids: structure-activity relationship studies

Previous studies have demonstrated that certain flavonoids can have an inhibitory effect on angiotensin-converting enzyme (ACE) activity, which plays a key role in the regulation of arterial blood pressure. In the present study, 17 flavonoids belonging to five structural subtypes were evaluated in v...

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Veröffentlicht in:	PloS one 2012-11, Vol.7 (11), p.e49493
Hauptverfasser:	Guerrero, Ligia, Castillo, Julián, Quiñones, Mar, Garcia-Vallvé, Santiago, Arola, Lluis, Pujadas, Gerard, Muguerza, Begoña
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Amino acids Angiotensin Angiotensin converting enzyme inhibitors Angiotensins Antihypertensives Biochemistry Biological activity Biology Biotechnology Blood pressure Cardiovascular disease Cardiovascular Diseases - drug therapy Catechol Catechols - chemistry Chemical properties Chemistry Chromatography, High Pressure Liquid - methods Computer Science Conversion Coronary vessels Docking Dose-Response Relationship, Drug Enzymatic activity Enzyme activity Enzymes Flavonoids Flavonoids - chemistry Humans Hypertension Inhibitory Concentration 50 Isoflavones Kaempferol Ligands Medicine Models, Chemical Models, Molecular Molecular Conformation Nutrition research Peptidyl-dipeptidase A Peptidyl-Dipeptidase A - chemistry Polyphenols Proteins Quercetin R&D Research & development Risk Factors Rutin Structure-Activity Relationship Studies Temperature
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