High CCR5 density on central memory CD4+ T cells in acute HIV-1 infection is mostly associated with rapid disease progression
CD4+ central memory T cells play a critical role in the pathogenesis of simian immunodeficiency virus disease, and the CCR5 density on the surface of CD4 T cells is an important factor in human immunodeficiency virus (HIV)-1 disease progression. We hypothesized that quantifying central memory cells...
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| Veröffentlicht in: | PloS one 2012-11, Vol.7 (11), p.e49526-e49526 |
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| creator | Yang, Xue Jiao, Yan-mei Wang, Rui Ji, Yun-xia Zhang, Hong-wei Zhang, Yong-hong Chen, De-xi Zhang, Tong Wu, Hao |
| description | CD4+ central memory T cells play a critical role in the pathogenesis of simian immunodeficiency virus disease, and the CCR5 density on the surface of CD4 T cells is an important factor in human immunodeficiency virus (HIV)-1 disease progression. We hypothesized that quantifying central memory cells and CCR5 expression in the early stages of HIV-infection could provide useful prognostic information. We enrolled two different groups of acute HIV-infected subjects. One group progressed to CD4 T cell numbers below 250 cells/µl within 2 years (CD4 Low group), while the other group maintained CD4 cell counts above 450 cells/µl over 2 years (CD4 High group). We compared the CCR5 levels and percentage of CD4 subsets between the two groups during the 1st year of HIV infection. We found no differences between the two groups regarding the percentage of naïve, central memory and effector memory subsets of CD4 cells during the 1st year of HIV-1 infection. CCR5 levels on CD4+ CM subset was higher in the CD4 Low group compared with the CD4 High group during the 1st year of HIV-1 infection. High CCR5 levels on CD4 central memory cells in acute HIV infection are mostly associated with rapid disease progression. Our data suggest that low CCR5 expression on CD4 central memory cells protects CD4 cells from direct virus infection and favors the preservation of CD4(+) T cell homeostasis. |
| doi_str_mv | 10.1371/journal.pone.0049526 |
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We hypothesized that quantifying central memory cells and CCR5 expression in the early stages of HIV-infection could provide useful prognostic information. We enrolled two different groups of acute HIV-infected subjects. One group progressed to CD4 T cell numbers below 250 cells/µl within 2 years (CD4 Low group), while the other group maintained CD4 cell counts above 450 cells/µl over 2 years (CD4 High group). We compared the CCR5 levels and percentage of CD4 subsets between the two groups during the 1st year of HIV infection. We found no differences between the two groups regarding the percentage of naïve, central memory and effector memory subsets of CD4 cells during the 1st year of HIV-1 infection. CCR5 levels on CD4+ CM subset was higher in the CD4 Low group compared with the CD4 High group during the 1st year of HIV-1 infection. High CCR5 levels on CD4 central memory cells in acute HIV infection are mostly associated with rapid disease progression. Our data suggest that low CCR5 expression on CD4 central memory cells protects CD4 cells from direct virus infection and favors the preservation of CD4(+) T cell homeostasis.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0049526</identifier><identifier>PMID: 23185351</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acquired immune deficiency syndrome ; Adult ; AIDS ; Antibodies, Monoclonal - chemistry ; Antiretroviral drugs ; Biology ; CCR5 protein ; CD4 antigen ; CD4 Lymphocyte Count ; CD4-Positive T-Lymphocytes - cytology ; Cell Separation ; Cohort Studies ; Computer memory ; Disease Progression ; Flow Cytometry ; HIV ; HIV Antigens - chemistry ; HIV Antigens - metabolism ; HIV-1 - metabolism ; Homeostasis ; Human immunodeficiency virus ; Humans ; Immunological memory ; Infections ; Lymphocytes ; Lymphocytes T ; Male ; Medicine ; Memory cells ; Middle Aged ; Pathogenesis ; Preservation ; Real-Time Polymerase Chain Reaction - methods ; Receptors, CCR5 - chemistry ; Receptors, CCR5 - metabolism ; Viruses</subject><ispartof>PloS one, 2012-11, Vol.7 (11), p.e49526-e49526</ispartof><rights>2012 Yang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2012 Yang et al 2012 Yang et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-606cbf8bcecb71c0ee51b794a3e27cb46f9c436af62d95f473b844b31a823bba3</citedby><cites>FETCH-LOGICAL-c526t-606cbf8bcecb71c0ee51b794a3e27cb46f9c436af62d95f473b844b31a823bba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504013/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504013/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27903,27904,53769,53771,79346,79347</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23185351$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Gray, Clive M.</contributor><creatorcontrib>Yang, Xue</creatorcontrib><creatorcontrib>Jiao, Yan-mei</creatorcontrib><creatorcontrib>Wang, Rui</creatorcontrib><creatorcontrib>Ji, Yun-xia</creatorcontrib><creatorcontrib>Zhang, Hong-wei</creatorcontrib><creatorcontrib>Zhang, Yong-hong</creatorcontrib><creatorcontrib>Chen, De-xi</creatorcontrib><creatorcontrib>Zhang, Tong</creatorcontrib><creatorcontrib>Wu, Hao</creatorcontrib><title>High CCR5 density on central memory CD4+ T cells in acute HIV-1 infection is mostly associated with rapid disease progression</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>CD4+ central memory T cells play a critical role in the pathogenesis of simian immunodeficiency virus disease, and the CCR5 density on the surface of CD4 T cells is an important factor in human immunodeficiency virus (HIV)-1 disease progression. We hypothesized that quantifying central memory cells and CCR5 expression in the early stages of HIV-infection could provide useful prognostic information. We enrolled two different groups of acute HIV-infected subjects. One group progressed to CD4 T cell numbers below 250 cells/µl within 2 years (CD4 Low group), while the other group maintained CD4 cell counts above 450 cells/µl over 2 years (CD4 High group). We compared the CCR5 levels and percentage of CD4 subsets between the two groups during the 1st year of HIV infection. We found no differences between the two groups regarding the percentage of naïve, central memory and effector memory subsets of CD4 cells during the 1st year of HIV-1 infection. CCR5 levels on CD4+ CM subset was higher in the CD4 Low group compared with the CD4 High group during the 1st year of HIV-1 infection. High CCR5 levels on CD4 central memory cells in acute HIV infection are mostly associated with rapid disease progression. Our data suggest that low CCR5 expression on CD4 central memory cells protects CD4 cells from direct virus infection and favors the preservation of CD4(+) T cell homeostasis.</description><subject>Acquired immune deficiency syndrome</subject><subject>Adult</subject><subject>AIDS</subject><subject>Antibodies, Monoclonal - chemistry</subject><subject>Antiretroviral drugs</subject><subject>Biology</subject><subject>CCR5 protein</subject><subject>CD4 antigen</subject><subject>CD4 Lymphocyte Count</subject><subject>CD4-Positive T-Lymphocytes - cytology</subject><subject>Cell Separation</subject><subject>Cohort Studies</subject><subject>Computer memory</subject><subject>Disease Progression</subject><subject>Flow Cytometry</subject><subject>HIV</subject><subject>HIV Antigens - chemistry</subject><subject>HIV Antigens - metabolism</subject><subject>HIV-1 - metabolism</subject><subject>Homeostasis</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Immunological memory</subject><subject>Infections</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Male</subject><subject>Medicine</subject><subject>Memory cells</subject><subject>Middle Aged</subject><subject>Pathogenesis</subject><subject>Preservation</subject><subject>Real-Time Polymerase Chain Reaction - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Xue</au><au>Jiao, Yan-mei</au><au>Wang, Rui</au><au>Ji, Yun-xia</au><au>Zhang, Hong-wei</au><au>Zhang, Yong-hong</au><au>Chen, De-xi</au><au>Zhang, Tong</au><au>Wu, Hao</au><au>Gray, Clive M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High CCR5 density on central memory CD4+ T cells in acute HIV-1 infection is mostly associated with rapid disease progression</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2012-11-21</date><risdate>2012</risdate><volume>7</volume><issue>11</issue><spage>e49526</spage><epage>e49526</epage><pages>e49526-e49526</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>CD4+ central memory T cells play a critical role in the pathogenesis of simian immunodeficiency virus disease, and the CCR5 density on the surface of CD4 T cells is an important factor in human immunodeficiency virus (HIV)-1 disease progression. We hypothesized that quantifying central memory cells and CCR5 expression in the early stages of HIV-infection could provide useful prognostic information. We enrolled two different groups of acute HIV-infected subjects. One group progressed to CD4 T cell numbers below 250 cells/µl within 2 years (CD4 Low group), while the other group maintained CD4 cell counts above 450 cells/µl over 2 years (CD4 High group). We compared the CCR5 levels and percentage of CD4 subsets between the two groups during the 1st year of HIV infection. We found no differences between the two groups regarding the percentage of naïve, central memory and effector memory subsets of CD4 cells during the 1st year of HIV-1 infection. CCR5 levels on CD4+ CM subset was higher in the CD4 Low group compared with the CD4 High group during the 1st year of HIV-1 infection. High CCR5 levels on CD4 central memory cells in acute HIV infection are mostly associated with rapid disease progression. Our data suggest that low CCR5 expression on CD4 central memory cells protects CD4 cells from direct virus infection and favors the preservation of CD4(+) T cell homeostasis.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23185351</pmid><doi>10.1371/journal.pone.0049526</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Acquired immune deficiency syndrome Adult AIDS Antibodies, Monoclonal - chemistry Antiretroviral drugs Biology CCR5 protein CD4 antigen CD4 Lymphocyte Count CD4-Positive T-Lymphocytes - cytology Cell Separation Cohort Studies Computer memory Disease Progression Flow Cytometry HIV HIV Antigens - chemistry HIV Antigens - metabolism HIV-1 - metabolism Homeostasis Human immunodeficiency virus Humans Immunological memory Infections Lymphocytes Lymphocytes T Male Medicine Memory cells Middle Aged Pathogenesis Preservation Real-Time Polymerase Chain Reaction - methods Receptors, CCR5 - chemistry Receptors, CCR5 - metabolism Viruses |
| title | High CCR5 density on central memory CD4+ T cells in acute HIV-1 infection is mostly associated with rapid disease progression |
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