Unique substrates secreted by the type VI secretion system of Francisella tularensis during intramacrophage infection

Gram-negative bacteria have evolved sophisticated secretion machineries specialized for the secretion of macromolecules important for their life cycles. The Type VI secretion system (T6SS) is the most widely spread bacterial secretion machinery and is encoded by large, variable gene clusters, often...

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Veröffentlicht in:	PloS one 2012-11, Vol.7 (11), p.e50473
Hauptverfasser:	Bröms, Jeanette E, Meyer, Lena, Sun, Kun, Lavander, Moa, Sjöstedt, Anders
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Analysis Animals Bacteria Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacterial Vaccines - immunology Bacterial Vaccines - pharmacology Bacteriology Beta lactamases beta-Lactamases - genetics beta-Lactamases - metabolism Biology Cell Line Cholera Cytoplasm Cytosol Ectopic expression Fluorescence Francisella tularensis Francisella tularensis - pathogenicity Francisella tularensis - physiology Gene clusters Genes, Reporter Genomic Islands - genetics Gram-negative bacteria Health aspects Infections Laboratories Life cycles Macromolecules Macrophages Macrophages - immunology Macrophages - microbiology Medicine Mice Molecular Sequence Data Pathogenicity Pathogens Proteins Pseudomonas aeruginosa Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - immunology Secretion Sequence Alignment Substrates Tularemia - prevention & control Vaccines Vaccines, Attenuated Virulence
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