Increased expression of the very low-density lipoprotein receptor mediates lipid accumulation in clear-cell renal cell carcinoma

Clear-cell renal cell carcinoma (RCC) is, in most cases, caused by loss of function of the tumor suppressor gene von Hippel-Lindau, resulting in constitutive activation of hypoxia-inducible factor (HIF)-1α and expression of hypoxia-induced genes in normoxic conditions. Clear-cell RCC cells are chara...

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Veröffentlicht in:	PloS one 2012-11, Vol.7 (11), p.e48694-e48694
Hauptverfasser:	Sundelin, Jeanna Perman, Ståhlman, Marcus, Lundqvist, Annika, Levin, Max, Parini, Paolo, Johansson, Martin E, Borén, Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Basic Medicine Biology Blood lipids Cancer and Oncology Cancer och onkologi Carcinoma, Renal Cell - metabolism Carcinoma, Renal Cell - pathology Cell and Molecular Biology Cell Line, Tumor Cell- och molekylärbiologi Cholesterol Clear cell-type renal cell carcinoma Clinical Medicine Diabetes Enzymes Excretion Gene expression Genes Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Hypoxia-inducible factors invivo Kidney cancer Kidney Neoplasms - metabolism Kidney Neoplasms - pathology Klinisk medicin Laboratories light Lipid Metabolism Lipids Lipoproteins Lipoproteins (very low density) Low density lipoprotein receptors Low density lipoproteins Medical and Health Sciences Medical Biotechnology Medicin och hälsovetenskap Medicine Medicinsk bioteknologi Medicinska och farmaceutiska grundvetenskaper Metabolism Pathology Physical characteristics quantification rabbit Receptor density Receptors, LDL - metabolism Renal cell carcinoma Rodents tissue Tumor suppressor genes
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