Alterations in cerebrospinal fluid proteins in a presymptomatic primary glioma model

Understanding the early relationship between brain tumor cells and their environment could lead to more sensitive biomarkers and new therapeutic strategies. We have been using a rodent model of neurocarcinogenesis in which all animals develop brain tumors by six months of age to establish two early...

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Veröffentlicht in:	PloS one 2012-11, Vol.7 (11), p.e49724
Hauptverfasser:	Whitin, John C, Jang, Taichang, Merchant, Milton, Yu, Tom T-S, Lau, Kenneth, Recht, Benjamin, Cohen, Harvey J, Recht, Lawrence
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Albumin Animals Arthritis Biology Biomarkers Biomarkers - metabolism Brain Brain - pathology Brain cancer Brain Neoplasms - cerebrospinal fluid Brain Neoplasms - metabolism Brain tumors Cerebrospinal fluid Cerebrospinal fluid proteins Cerebrospinal Fluid Proteins - metabolism Chi-square test Disease Models, Animal Ethylnitrosourea - pharmacology Exposure Gene Expression Regulation, Neoplastic Glioma Glioma - cerebrospinal fluid Glioma - metabolism Gliomas Glutathione Glutathione - metabolism Health aspects Hyperplasia Intermediate Filament Proteins - biosynthesis Mass spectrometry Mass spectroscopy Medicine Nerve Tissue Proteins - biosynthesis Nestin Neurology NMR Nuclear magnetic resonance Oxidative stress Pediatrics Protein composition Protein expression Proteins Proteome Proteomes Proteomics Proteomics - methods Rats Rats, Sprague-Dawley Rodents Studies Time Factors Transthyretin Tumor cells Tumors
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