Valproic acid induces cutaneous wound healing in vivo and enhances keratinocyte motility

Cutaneous wound healing is a complex process involving several signaling pathways such as the Wnt and extracellular signal-regulated kinase (ERK) signaling pathways. Valproic acid (VPA) is a commonly used antiepileptic drug that acts on these signaling pathways; however, the effect of VPA on cutaneo...

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Veröffentlicht in:	PloS one 2012-11, Vol.7 (11), p.e48791-e48791
Hauptverfasser:	Lee, Soung-Hoon, Zahoor, Muhammad, Hwang, Jae-Kwan, Min, Do Sik, Choi, Kang-Yell
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Acids Actin Actins AKT protein Animal models Animals Antiepileptic agents Apoptosis Apoptosis - drug effects beta Catenin - metabolism Biology Biotechnology Cancer Cell adhesion & migration Cell Differentiation - drug effects Cell Line Cell Movement - drug effects Cell proliferation Collagen Collagen (type I) Collagen (type III) Collagen Type I - metabolism Collagen Type III - metabolism DNA nucleotidylexotransferase Epidermis Extracellular signal-regulated kinase Fibroblasts Growth factors Humans In Situ Nick-End Labeling Keratin Keratinocytes Keratinocytes - drug effects Kinases Laboratory animals Life sciences MAP Kinase Signaling System Medicine Mice Mice, Inbred C3H Motility Muscle proteins Muscles Phosphatidylinositol 3-Kinase - metabolism Prostate Proteins Proto-Oncogene Proteins c-akt - metabolism Rodents Signal processing Signal transduction Signaling Smooth muscle Stem cells Valproic acid Valproic Acid - pharmacology Valproic Acid - therapeutic use Wnt protein Wnt Proteins - metabolism Wound care Wound healing Wound Healing - drug effects β-Catenin
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