MitoQ blunts mitochondrial and renal damage during cold preservation of porcine kidneys

Cold preservation has greatly facilitated the use of cadaveric kidneys for transplantation but damage occurs during the preservation episode. It is well established that oxidant production increases during cold renal preservation and mitochondria are a key target for injury. Our laboratory has demon...

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Veröffentlicht in:	PloS one 2012-11, Vol.7 (11), p.e48590
Hauptverfasser:	Parajuli, Nirmala, Campbell, Lia H, Marine, Akira, Brockbank, Kelvin G M, Macmillan-Crow, Lee Ann
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdomen Animal models Animals Antioxidants Apoptosis Biochemistry Biology Biosynthesis Buffers Cadavers Cell death Cell Death - drug effects Cold storage Coronary vessels Cryopreservation Cytochrome Disease Electron transport Electron Transport - drug effects Electron transport chain Hogs In Situ Nick-End Labeling Ischemia Kidney transplantation Kidney Tubules - drug effects Kidney Tubules - pathology Kidneys Laboratory animals Male Medicine Mitochondria Mitochondria - drug effects Mitochondria - pathology Mortality Nitrosation - drug effects Nitrotyrosine Organ Preservation Organophosphorus Compounds - pharmacology Oxidative stress Oxidative Stress - drug effects Oxidizing agents Pharmacology Proteins - metabolism Rats Respirometry Rodents Storage Superoxide Superoxides Sus scrofa Toxicology Transplantation Transplants & implants Ubiquinone - analogs & derivatives Ubiquinone - pharmacology
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