LDx: estimation of linkage disequilibrium from high-throughput pooled resequencing data

High-throughput pooled resequencing offers significant potential for whole genome population sequencing. However, its main drawback is the loss of haplotype information. In order to regain some of this information, we present LDx, a computational tool for estimating linkage disequilibrium (LD) from...

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Veröffentlicht in:	PloS one 2012-11, Vol.7 (11), p.e48588-e48588
Hauptverfasser:	Feder, Alison F, Petrov, Dmitri A, Bergland, Alan O
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Animals Bioinformatics Biology Computer applications Computer simulation Demographics Demography Deoxyribonucleic acid Depth perception DNA Drosophila melanogaster Drosophila melanogaster - genetics Estimates Gene loci Gene sequencing Genetic aspects Genetic Loci Genetic testing Genetics Genomes Genomics Haplotypes High-Throughput Nucleotide Sequencing Insects Internet Linkage Disequilibrium Mathematics Maximum likelihood estimates Medicine Methods Polymorphism, Single Nucleotide Population Reproducibility of Results Sequence Analysis, DNA Simulation Software Studies
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