Targeting the acute promyelocytic leukemia-associated fusion proteins PML/RARα and PLZF/RARα with interfering peptides

In acute promyelocytic leukemia (APL), hematopoietic differentiation is blocked and immature blasts accumulate in the bone marrow and blood. APL is associated with chromosomal aberrations, including t(15;17) and t(11;17). For these two translocations, the retinoic acid receptor alpha (RARα) is fused...

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Veröffentlicht in:	PloS one 2012-11, Vol.7 (11), p.e48636-e48636
Hauptverfasser:	Beez, Sabine, Demmer, Philipp, Puccetti, Elena
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Acids Acute promyeloid leukemia Animals Biology Bone marrow Cancer Cell Differentiation - genetics Cell Line Chromosome aberrations Chromosome translocations Complex formation Differentiation Enzymes Fusion protein Gene Expression Hematopoietic stem cells Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Humans Leukemia Leukemia, Promyelocytic, Acute - genetics Leukemia, Promyelocytic, Acute - metabolism Ligands Medicine Mice Molecular biology Molecular Weight Multiprotein Complexes - chemistry Multiprotein Complexes - metabolism Mutation Oligomerization Oncogene Proteins, Fusion - chemistry Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - metabolism Peptides Peptides - chemistry Peptides - genetics Peptides - metabolism Plasmids Polypeptides Promyeloid leukemia Protein Binding Protein Multimerization Proteins Proteolysis Retinoic acid Small Ubiquitin-Related Modifier Proteins - metabolism Stability analysis Stem cell transplantation Stem cells Transcription factors Tretinoin Zinc Zinc finger proteins
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