Doxorubicin influences the expression of glucosylceramide synthase in invasive ductal breast cancer

Glucosylceramide synthase (GCS) is one enzyme that provides a major route for ceramide clearance. Recent evidence has indicated an important role for GCS in multidrug resistance (MDR) tumors. Doxorubicin (DOX)can modulate the expression of GCS in leukemia and ovary cell lines. However, few studies h...

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Veröffentlicht in:	PloS one 2012-11, Vol.7 (11), p.e48492-e48492
Hauptverfasser:	Zhang, Xiaofang, Wu, Xiaojuan, Su, Peng, Gao, Yongsheng, Meng, Bin, Sun, Yanlin, Li, Li, Zhou, Zhiqiang, Zhou, Gengyin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Analysis Anthracyclines Antibiotics, Antineoplastic - pharmacology Apoptosis Biology Biotechnology Breast cancer Cancer Cancer therapies Carcinoma, Ductal, Breast - drug therapy Carcinoma, Ductal, Breast - enzymology Care and treatment Cell culture Cell Line, Tumor Ceramide Ceramide glucosyltransferase Chemotherapy Doxorubicin Doxorubicin - pharmacology Enzymes Estrogen Receptor alpha - metabolism Female Gene expression Gene Expression Profiling Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Glucosyltransferases - biosynthesis Humans Immunohistochemistry Immunohistochemistry - methods Invasiveness Leukemia Medical research Medicine Microbial drug resistance Middle Aged mRNA Multidrug resistance Pathology Patients Promoter Regions, Genetic Proteins RNA RNA, Messenger - metabolism Sp1 protein Tumor cell lines Tumors
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