Mice genetically depleted of brain serotonin display social impairments, communication deficits and repetitive behaviors: possible relevance to autism

Autism is a complex neurodevelopmental disorder characterized by impaired reciprocal social interaction, communication deficits and repetitive behaviors. A very large number of genes have been linked to autism, many of which encode proteins involved in the development and function of synaptic circui...

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Veröffentlicht in:	PloS one 2012-11, Vol.7 (11), p.e48975-e48975
Hauptverfasser:	Kane, Michael J, Angoa-Peréz, Mariana, Briggs, Denise I, Sykes, Catherine E, Francescutti, Dina M, Rosenberg, David R, Kuhn, Donald M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggressiveness Animal Communication Animals Animals, Newborn Anxiety - complications Autism Autistic Disorder - genetics Autistic Disorder - pathology Behavior Biology Brain Brain - metabolism Brain - pathology Brain research Circuits Compulsive Behavior - complications Compulsive Behavior - genetics Developmental stages Enzymes Female Gene Knockout Techniques Gene mutation Genes Genetic aspects Male Medicine Memory Mice Mice, Inbred C57BL Mutation Network formation Neurodevelopmental disorders Neurons Neurophysiology Neurosciences Odorants Organ Size Phenols (Class of compounds) Proteins Psychiatry R&D Research & development Scents Serotonin Serotonin - deficiency Serotonin - metabolism Social aspects Social Behavior Synaptogenesis Tryptophan Tryptophan hydroxylase Tryptophan Hydroxylase - deficiency Tryptophan Hydroxylase - metabolism Weaning
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