Mannose-binding lectin regulates host resistance and pathology during experimental infection with Trypanosoma cruzi

Mannose-binding lectin (MBL) is a humoral pattern-recognition molecule important for host defense. Although recent genetic studies suggest an involvement of MBL/MASP2-associated pathways in Chagas' disease, it is currently unknown whether MBL plays a role in host resistance to the intracellular...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2012-11, Vol.7 (11), p.e47835-e47835
Hauptverfasser:	Rothfuchs, Antonio Gigliotti, Roffê, Ester, Gibson, Amanda, Cheever, Allen W, Ezekowitz, R Alan B, Takahashi, Kazue, Steindel, Mario, Sher, Alan, Báfica, André
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Biology Cardiomyopathies - blood Cardiomyopathies - parasitology Cardiomyopathies - pathology Chagas Disease - blood Chagas Disease - parasitology Chagas Disease - pathology Collagen Disease Resistance - immunology Experimental infection Fibrosis Gene expression Health aspects Heart Heart diseases Host-Parasite Interactions - immunology Humans Hydroxyproline Infection Inflammation Interleukin 12 Interleukin-12 Subunit p40 - biosynthesis Lectins Mannose Mannose-binding lectin Mannose-Binding Lectin - blood Mannose-Binding Lectin - deficiency Mannose-Binding Lectin - metabolism MASP-2 protein Medical research Medicine Mice Microbial drug resistance Monosaccharides mRNA Myocarditis Myocardium - pathology Parasite Load Parasites Parasitic diseases Patients Pattern recognition Protozoa RNA Studies Trypanosoma cruzi Trypanosoma cruzi - physiology Vector-borne diseases
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!