Updating the salivary gland transcriptome of Phlebotomus papatasi (Tunisian strain): the search for sand fly-secreted immunogenic proteins for humans

Sand fly saliva plays an important role in both blood feeding and outcome of Leishmania infection. A cellular immune response against a Phlebotomus papatasi salivary protein was shown to protect rodents against Leishmania major infection. In humans, P. papatasi salivary proteins induce a systemic ce...

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Veröffentlicht in:	PloS one 2012-11, Vol.7 (11), p.e47347-e47347
Hauptverfasser:	Abdeladhim, Maha, Jochim, Ryan C, Ben Ahmed, Melika, Zhioua, Elyes, Chelbi, Ifhem, Cherni, Saifedine, Louzir, Hechmi, Ribeiro, José M C, Valenzuela, Jesus G
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Anopheles - metabolism Anticoagulants - chemistry Anticoagulants - metabolism Biology Biomarkers - metabolism Comparative analysis Exposure Feeding Behavior - physiology Female Gene expression Genomic libraries Genomics Geography Glands Glossina morsitans morsitans Health aspects Human health and pathology Humans Immune response Immune response (cell-mediated) Immune response (humoral) Immune system Immunogenicity Infection Infections Infectious diseases Insect Proteins - chemistry Insect Proteins - genetics Insect Proteins - secretion Insect Vectors - immunology Laboratories Leishmania Leishmania major Life Sciences Lutzomyia longipalpis Malaria Markers Medicine Molecular biology Molecular interactions Molecular Sequence Data Molecular Weight Multigene Family Parasites Parasitic diseases Peptides Phlebotomus - genetics Phlebotomus - immunology Phylogeny Proteins Rodents Saliva Salivary gland Salivary glands Salivary Glands - immunology Salivary Glands - secretion Sand Sequence Alignment Transcriptome - genetics Tropical diseases Tunisia Veterinary Science
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