The Association between genetic variations of CHI3L1, levels of the encoded glycoprotein YKL-40 and the lipid profile in a Danish population

The inflammatory biomarker YKL-40 seems to play a role in atherosclerosis and is elevated in patients with obesity, cardiovascular disease and type 2 diabetes. Single nucleotide polymorphisms (SNPs) of the YKL-40 encoding gene, CHI3L1, are associated with inter-individual YKL-40 levels. One study ha...

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Veröffentlicht in:	PloS one 2012-10, Vol.7 (10), p.e47094-e47094
Hauptverfasser:	Thomsen, Stine Brinkløv, Rathcke, Camilla Noelle, Skaaby, Tea, Linneberg, Allan, Vestergaard, Henrik
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipokines - genetics Adult Aged Arteriosclerosis Atherosclerosis Biology Biomarkers Cardiac patients Cardiovascular disease Cardiovascular diseases Chitinase-3-Like Protein 1 Cholesterol Chromosomes Denmark Density Diabetes mellitus European Continental Ancestry Group - genetics Female Gene polymorphism Genetic aspects Genetic diversity Genetic Predisposition to Disease Genetic research Genotypes Glycoproteins Homozygosity Humans Hypercholesterolemia Hypercholesterolemia - genetics Inflammation Insulin resistance Kinases Lectins - genetics Lipids - blood Lipids - genetics Lipoproteins, HDL - blood Lipoproteins, HDL - genetics Lipoproteins, LDL - blood Lipoproteins, LDL - genetics Male Medicine Middle Aged Obesity Polymorphism Polymorphism, Single Nucleotide Promoter Regions, Genetic Replication Single nucleotide polymorphisms Single-nucleotide polymorphism Studies Triglycerides Triglycerides - blood Triglycerides - genetics Type 2 diabetes
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