Comparative study of human and mouse postsynaptic proteomes finds high compositional conservation and abundance differences for key synaptic proteins

Direct comparison of protein components from human and mouse excitatory synapses is important for determining the suitability of mice as models of human brain disease and to understand the evolution of the mammalian brain. The postsynaptic density is a highly complex set of proteins organized into m...

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Veröffentlicht in:	PloS one 2012-10, Vol.7 (10), p.e46683-e46683
Hauptverfasser:	Bayés, Alex, Collins, Mark O, Croning, Mike D R, van de Lagemaat, Louie N, Choudhary, Jyoti S, Grant, Seth G N
Format:	Artikel
Sprache:	eng
Schlagworte:	Abundance Adaptor proteins Alzheimer's disease Alzheimers disease Animal cognition Animal models Animals Biodiversity Biology Brain Centrifugation, Density Gradient Cerebral Cortex - cytology Cerebral Cortex - metabolism Chromatography, Gel Clinical medicine Comparative analysis Comparative studies Complexity Conservation Cortex Dendritic spines Dendritic structure Density Evolution Evolution (Biology) Evolutionary biology Female Fractionation Gene expression Genomes Glutamatergic transmission Humans Kinases Laboratories Male Mass spectrometry Medicine Mice Mice, 129 Strain Nerve Tissue Proteins - isolation & purification Nerve Tissue Proteins - metabolism Neurosciences Neurotransmitter receptors Post-Synaptic Density - metabolism Postsynaptic density Postsynaptic density proteins Protein Interaction Maps Proteins Proteome - isolation & purification Proteome - metabolism Proteomes Quantitative analysis Receptors Schizophrenia Scientific imaging Species Species diversity Species Specificity Spine Synapses Synapses - metabolism Tandem Mass Spectrometry Trends
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