Slit2N/Robo1 inhibit HIV-gp120-induced migration and podosome formation in immature dendritic cells by sequestering LSP1 and WASp

Cell-mediated transmission and dissemination of sexually-acquired human immunodeficiency virus 1 (HIV-1) in the host involves the migration of immature dendritic cells (iDCs). iDCs migrate in response to the HIV-1 envelope protein, gp120, and inhibiting such migration may limit the mucosal transmiss...

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Veröffentlicht in:	PloS one 2012-10, Vol.7 (10), p.e48854-e48854
Hauptverfasser:	Prasad, Anil, Kuzontkoski, Paula M, Shrivastava, Ashutosh, Zhu, Weiquan, Li, Dean Y, Groopman, Jerome E
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actin-related protein 2 Actin-Related Protein 2-3 Complex - immunology Actin-Related Protein 2-3 Complex - metabolism Actins - immunology Actins - metabolism Angiogenesis Biology Blotting, Western cdc42 GTP-Binding Protein - immunology cdc42 GTP-Binding Protein - metabolism Cdc42 protein Cell adhesion & migration Cell Movement - immunology Cells, Cultured Dendritic cells Dendritic Cells - immunology Dendritic Cells - metabolism Disease transmission Focal Adhesion Kinase 2 - immunology Focal Adhesion Kinase 2 - metabolism Glycoprotein gp120 Glycoproteins HIV HIV Envelope Protein gp120 - immunology HIV Envelope Protein gp120 - metabolism Human immunodeficiency virus Human Umbilical Vein Endothelial Cells - immunology Human Umbilical Vein Endothelial Cells - metabolism Humans Intercellular Signaling Peptides and Proteins - immunology Intercellular Signaling Peptides and Proteins - metabolism Kinases Leukocyte migration Leukocytes Ligands Localization LSP1 protein Medical schools Medicine Microfilament Proteins - genetics Microfilament Proteins - immunology Microfilament Proteins - metabolism Microscopy, Confocal Motility Mucosa Muscle proteins Nerve Tissue Proteins - immunology Nerve Tissue Proteins - metabolism Paxillin Paxillin - immunology Paxillin - metabolism Protein binding Protein Binding - immunology Proteins Proto-Oncogene Proteins pp60(c-src) - immunology Proto-Oncogene Proteins pp60(c-src) - metabolism Pseudopodia - immunology rac1 GTP-Binding Protein - immunology rac1 GTP-Binding Protein - metabolism Rac1 protein Receptors, Immunologic - immunology Receptors, Immunologic - metabolism RNA Interference Roundabout Proteins Sequestering Sexually transmitted diseases Signal Transduction - immunology Signaling Smooth muscle STD Tissues Viral envelope proteins Viruses Wiskott-Aldrich syndrome Wiskott-Aldrich Syndrome Protein - immunology Wiskott-Aldrich Syndrome Protein - metabolism
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