Long-term culture of astrocytes attenuates the readily releasable pool of synaptic vesicles

The astrocyte is a major glial cell type of the brain, and plays key roles in the formation, maturation, stabilization and elimination of synapses. Thus, changes in astrocyte condition and age can influence information processing at synapses. However, whether and how aging astrocytes affect synaptic...

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Veröffentlicht in:	PloS one 2012-10, Vol.7 (10), p.e48034-e48034
Hauptverfasser:	Kawano, Hiroyuki, Katsurabayashi, Shutaro, Kakazu, Yasuhiro, Yamashita, Yuta, Kubo, Natsuko, Kubo, Masafumi, Okuda, Hideto, Takasaki, Kotaro, Kubota, Kaori, Mishima, Kenichi, Fujiwara, Michihiro, Harata, N Charles, Iwasaki, Katsunori
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals Animals, Newborn Astrocytes Astrocytes - cytology Astrocytes - metabolism Astrocytes - physiology beta-Galactosidase - metabolism Biology Biophysics Brain Brain - cytology Brain - metabolism Brain research Cell culture Cells, Cultured Cellular Senescence - physiology Cerebral cortex Coculture Techniques Collaboration Data processing Evaluation Excitatory Postsynaptic Potentials - physiology Galactosidase Glial cells Glial fibrillary acidic protein Glial Fibrillary Acidic Protein - metabolism Glutamate Glutamic Acid - metabolism Glutamic acid receptors (ionotropic) Hippocampus Immunohistochemistry Information processing Intermediate filament proteins Kinases Maturation Mice Mice, Inbred ICR Microscopy, Confocal N-Methyl-D-aspartic acid receptors Nerve endings Neuronal-glial interactions Neurons Neurons - cytology Neurons - metabolism Neurons - physiology Neurophysiology Patch-Clamp Techniques Pharmaceutical sciences Physiology Proteins Receptors Receptors, Glutamate - metabolism Receptors, N-Methyl-D-Aspartate - metabolism Senescence Synapses Synaptic transmission Synaptic Transmission - physiology Synaptic vesicles Synaptic Vesicles - physiology Synaptic Vesicles - secretion Synaptogenesis Time Factors Vesicles α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid β-Galactosidase
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