Genomic expression analyses reveal lysosomal, innate immunity proteins, as disease correlates in murine models of a lysosomal storage disorder

Niemann-Pick Type C (NPC) disease is a rare, genetic, lysosomal disorder with progressive neurodegeneration. Poor understanding of the pathophysiology and a lack of blood-based diagnostic markers are major hurdles in the treatment and management of NPC and several additional, neurological lysosomal...

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Veröffentlicht in:	PloS one 2012-10, Vol.7 (10), p.e48273-e48273
Hauptverfasser:	Alam, Md Suhail, Getz, Michelle, Safeukui, Innocent, Yi, Sue, Tamez, Pamela, Shin, Jenny, Velázquez, Peter, Haldar, Kasturi
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aging - genetics Aging - immunology Aging - pathology Analysis Animal models Animals Bacteria Bacterial diseases Biology Biomarkers Biomarkers - blood Brain Brain - immunology Brain - metabolism Care and treatment Cholesterol Damage detection Diagnosis Diagnostic systems Disease Disease Progression Female Gaucher's disease Gene Expression Gene regulation Genes Genetic engineering Genomes Humans Immunity Immunity (Disease) Immunity, Innate Immunohistochemistry Infections Innate immunity Intracellular Signaling Peptides and Proteins Leukocytes (neutrophilic) Liver Liver - immunology Liver - metabolism Liver diseases Lysosomes Lysosomes - genetics Lysosomes - immunology Lysosomes - metabolism Lysozyme Male Markers Medicine Mice Mice, Knockout Muramidase - blood Muramidase - genetics Mutants Mutation Neurodegeneration Neurological diseases Neutrophil Infiltration Neutrophils Neutrophils - immunology Neutrophils - metabolism Niemann-Pick disease Niemann-Pick Disease, Type C - genetics Niemann-Pick Disease, Type C - immunology Niemann-Pick Disease, Type C - pathology Npc1 protein Organs Pathophysiology Plasma Point mutation Proteins Proteins - genetics Proteins - immunology Proteins - metabolism Salmonella Spleen Spleen - immunology Spleen - metabolism Storage Tumor necrosis factor-TNF
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