Multiple analyses of G-protein coupled receptor (GPCR) expression in the development of gefitinib-resistance in transforming non-small-cell lung cancer

There is increasing evidence that functional crosstalk between GPCRs and EGFR contributes to the progression of colon, lung, breast, ovarian, prostate and head and neck tumors. In this study, we performed multiple analyses of GPCR expression in a gefitinib-resistant non-small cell lung cancer (NSCLC...

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Veröffentlicht in:	PloS one 2012-10, Vol.7 (10), p.e44368
Hauptverfasser:	Kuzumaki, Naoko, Suzuki, Atsuo, Narita, Michiko, Hosoya, Takahiro, Nagasawa, Atsumi, Imai, Satoshi, Yamamizu, Kohei, Morita, Hiroshi, Suzuki, Tsutomu, Okada, Yohei, Okano, Hirotaka James, Yamashita, Jun K, Okano, Hideyuki, Narita, Minoru
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine A2 Receptor Antagonists - pharmacology Adenosine A2A receptors Analysis Antineoplastic Agents - pharmacology Biology Blotting, Western Cancer Cancer therapies Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - pathology Cell Line, Tumor Cell Survival - drug effects Cell Survival - genetics Cells, Cultured Colon Crosstalk DNA microarrays Dose-Response Relationship, Drug Drug Resistance, Neoplasm - genetics Epidermal growth factor Epidermal growth factor receptors Fibroblasts - cytology Fibroblasts - metabolism G protein-coupled receptors Gefitinib Head Head and neck Humans Inhibitor drugs Kinases Laboratories Ligands Lung - cytology Lung - metabolism Lung cancer Lung diseases Lung Neoplasms - genetics Lung Neoplasms - pathology Medical research Medicine Mutation Non-small cell lung cancer Non-small cell lung carcinoma Oligonucleotide Array Sequence Analysis Pharmaceutical sciences Pharmacy Phosphorylation Physiology Prostate Proteins Pyrimidines - pharmacology Quinazolines - pharmacology Receptor, Adenosine A2A - genetics Receptors Receptors, G-Protein-Coupled - antagonists & inhibitors Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Reverse Transcriptase Polymerase Chain Reaction Ribonucleic acid RNA RNA Interference Signaling siRNA Small cell lung carcinoma Stem cells Targeted cancer therapy Transcriptome Trends Triazoles - pharmacology Tumorigenesis Tumors
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