Antibacterial activity of polymer coated cerium oxide nanoparticles
Cerium oxide nanoparticles have found numerous applications in the biomedical industry due to their strong antioxidant properties. In the current study, we report the influence of nine different physical and chemical parameters: pH, aeration and, concentrations of MgSO(4), CaCl(2), KCl, natural orga...
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| Veröffentlicht in: | PloS one 2012-10, Vol.7 (10), p.e47827 |
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| creator | Shah, Vishal Shah, Shreya Shah, Hirsh Rispoli, Fred J McDonnell, Kevin T Workeneh, Selam Karakoti, Ajay Kumar, Amit Seal, Sudipta |
| description | Cerium oxide nanoparticles have found numerous applications in the biomedical industry due to their strong antioxidant properties. In the current study, we report the influence of nine different physical and chemical parameters: pH, aeration and, concentrations of MgSO(4), CaCl(2), KCl, natural organic matter, fructose, nanoparticles and Escherichia coli, on the antibacterial activity of dextran coated cerium oxide nanoparticles. A least-squares quadratic regression model was developed to understand the collective influence of the tested parameters on the anti-bacterial activity and subsequently a computer-based, interactive visualization tool was developed. The visualization allows us to elucidate the effect of each of the parameters in combination with other parameters, on the antibacterial activity of nanoparticles. The results indicate that the toxicity of CeO(2) NPs depend on the physical and chemical environment; and in a majority of the possible combinations of the nine parameters, non-lethal to the bacteria. In fact, the cerium oxide nanoparticles can decrease the anti-bacterial activity exerted by magnesium and potassium salts. |
| doi_str_mv | 10.1371/journal.pone.0047827 |
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In the current study, we report the influence of nine different physical and chemical parameters: pH, aeration and, concentrations of MgSO(4), CaCl(2), KCl, natural organic matter, fructose, nanoparticles and Escherichia coli, on the antibacterial activity of dextran coated cerium oxide nanoparticles. A least-squares quadratic regression model was developed to understand the collective influence of the tested parameters on the anti-bacterial activity and subsequently a computer-based, interactive visualization tool was developed. The visualization allows us to elucidate the effect of each of the parameters in combination with other parameters, on the antibacterial activity of nanoparticles. The results indicate that the toxicity of CeO(2) NPs depend on the physical and chemical environment; and in a majority of the possible combinations of the nine parameters, non-lethal to the bacteria. In fact, the cerium oxide nanoparticles can decrease the anti-bacterial activity exerted by magnesium and potassium salts.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0047827</identifier><identifier>PMID: 23110109</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aeration ; Anti-Bacterial Agents - toxicity ; Antibacterial activity ; Antibacterial agents ; Antioxidants ; Bacteria ; Biocompatibility ; Biology ; Calcium chloride ; Calcium Chloride - metabolism ; Cerium ; Cerium - toxicity ; Cerium oxides ; Chlorides ; Computer science ; Cytotoxicity ; Dextran ; Dextrans ; E coli ; Engineering ; Escherichia coli ; Escherichia coli - drug effects ; Factorial experiments ; Fructose ; Fructose - metabolism ; Humic acids ; Hydrogen-Ion Concentration ; Least-Squares Analysis ; Magnesium ; Magnesium Sulfate - metabolism ; Materials Science ; Metal Nanoparticles - chemistry ; Metal Nanoparticles - ultrastructure ; Microscopy, Electron, Transmission ; Models, Biological ; Nanoparticles ; Nitrosomonas europaea ; Organic matter ; Particle size ; pH effects ; Polymer coatings ; Polymer industry ; Potassium ; Potassium chloride ; Potassium Chloride - metabolism ; Potassium salts ; Rare earth metal compounds ; Regression models ; Salts ; Spectrophotometry, Ultraviolet ; Studies ; Toxicity ; Visualization</subject><ispartof>PloS one, 2012-10, Vol.7 (10), p.e47827</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>2012 Shah et al. 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In the current study, we report the influence of nine different physical and chemical parameters: pH, aeration and, concentrations of MgSO(4), CaCl(2), KCl, natural organic matter, fructose, nanoparticles and Escherichia coli, on the antibacterial activity of dextran coated cerium oxide nanoparticles. A least-squares quadratic regression model was developed to understand the collective influence of the tested parameters on the anti-bacterial activity and subsequently a computer-based, interactive visualization tool was developed. The visualization allows us to elucidate the effect of each of the parameters in combination with other parameters, on the antibacterial activity of nanoparticles. The results indicate that the toxicity of CeO(2) NPs depend on the physical and chemical environment; and in a majority of the possible combinations of the nine parameters, non-lethal to the bacteria. In fact, the cerium oxide nanoparticles can decrease the anti-bacterial activity exerted by magnesium and potassium salts.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23110109</pmid><doi>10.1371/journal.pone.0047827</doi><tpages>e47827</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aeration Anti-Bacterial Agents - toxicity Antibacterial activity Antibacterial agents Antioxidants Bacteria Biocompatibility Biology Calcium chloride Calcium Chloride - metabolism Cerium Cerium - toxicity Cerium oxides Chlorides Computer science Cytotoxicity Dextran Dextrans E coli Engineering Escherichia coli Escherichia coli - drug effects Factorial experiments Fructose Fructose - metabolism Humic acids Hydrogen-Ion Concentration Least-Squares Analysis Magnesium Magnesium Sulfate - metabolism Materials Science Metal Nanoparticles - chemistry Metal Nanoparticles - ultrastructure Microscopy, Electron, Transmission Models, Biological Nanoparticles Nitrosomonas europaea Organic matter Particle size pH effects Polymer coatings Polymer industry Potassium Potassium chloride Potassium Chloride - metabolism Potassium salts Rare earth metal compounds Regression models Salts Spectrophotometry, Ultraviolet Studies Toxicity Visualization |
| title | Antibacterial activity of polymer coated cerium oxide nanoparticles |
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