Evaluation of IL-28B polymorphisms and serum IP-10 in hepatitis C infected chimpanzees

In humans, clearance of hepatitis C virus (HCV) infection is associated with genetic variation near the IL-28B gene and the induction of interferon-stimulated genes, like IP-10. Also in chimpanzees spontaneous clearance of HCV is observed. To study whether similar correlations exist in these animals...

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Veröffentlicht in:	PloS one 2012-10, Vol.7 (10), p.e46645-e46645
Hauptverfasser:	Verstrepen, Babs E, de Groot, Natasja G, Groothuismink, Zwier M A, Verschoor, Ernst J, de Groen, Rik A, Bogers, Willy M, Janssen, Harry L A, Mooij, Petra, Bontrop, Ronald E, Koopman, Gerrit, Boonstra, Andre
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological response modifiers Biology Chemokine CXCL10 - blood Chemokine CXCL10 - genetics Chemokine CXCL10 - metabolism Chimpanzees Comparative analysis Correlation Correlation analysis Gastroenterology Gene polymorphism Gene sequencing Genes Genetic aspects Genetic Association Studies Genetic diversity Genomics Genotype Genotypes Health aspects Hepacivirus - genetics Hepacivirus - pathogenicity Hepatitis Hepatitis C Hepatitis C - blood Hepatitis C - genetics Hepatitis C - virology Hepatitis C virus Hepatology Humans Infection Infections Interferon Interferons Interleukins - genetics Interleukins - metabolism IP-10 protein Liver Medical research Medicine Molecular Sequence Data Pan troglodytes - blood Pan troglodytes - genetics Pan troglodytes - virology Patients Polymorphism Polymorphism, Single Nucleotide Proteins Ribonucleic acid RNA Single nucleotide polymorphisms Single-nucleotide polymorphism Viral Load Virology Viruses
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