The ubiquitin ligase Nedd4-1 participates in denervation-induced skeletal muscle atrophy in mice

Skeletal muscle atrophy is a consequence of muscle inactivity resulting from denervation, unloading and immobility. It accompanies many chronic disease states and also occurs as a pathophysiologic consequence of normal aging. In all these conditions, ubiquitin-dependent proteolysis is a key regulato...

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Veröffentlicht in:	PloS one 2012-10, Vol.7 (10), p.e46427-e46427
Hauptverfasser:	Nagpal, Preena, Plant, Pamela J, Correa, Judy, Bain, Alexandra, Takeda, Michiko, Kawabe, Hiroshi, Rotin, Daniela, Bain, James R, Batt, Jane A E
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals Atrophy Biology Blotting, Western Cells, Cultured Chronic diseases Chronic illnesses Chronic obstructive pulmonary disease Denervation Endosomal Sorting Complexes Required for Transport - genetics Endosomal Sorting Complexes Required for Transport - metabolism Enzymes Female Fibroblast growth factor receptor 1 Flox Gastrocnemius muscle Immunohistochemistry Kinases Ligases Male Medicine Mice Mice, Knockout Muscle Denervation Muscles Muscular Atrophy - genetics Muscular Atrophy - metabolism Musculoskeletal system Myoblasts - cytology Myoblasts - metabolism Nedd4 Ubiquitin Protein Ligases Neurobiology Neurosciences Notch1 protein Phosphatase Protein Tyrosine Phosphatases, Non-Receptor - genetics Protein Tyrosine Phosphatases, Non-Receptor - metabolism Proteins Proteolysis Receptor, Fibroblast Growth Factor, Type 1 - genetics Receptor, Fibroblast Growth Factor, Type 1 - metabolism Receptor, Notch1 - genetics Receptor, Notch1 - metabolism Rodents Satellite Cells, Skeletal Muscle - cytology Satellite Cells, Skeletal Muscle - metabolism Skeletal muscle Substrates Tibial nerve Ubiquitin Ubiquitin-protein ligase Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Unloading
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