The role of VEGF and KDR polymorphisms in moyamoya disease and collateral revascularization
We conducted a case-control study to investigate whether vascular endothelial growth factor (VEGF -2578, -1154, -634, and 936) and kinase insert domain containing receptor (KDR -604, 1192, and 1719) polymorphisms are associated with moyamoya disease. Korean patients with moyamoya disease (n = 107, m...
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| creator | Park, Young Seok Jeon, Young Joo Kim, Hyun Seok Chae, Kyu Young Oh, Seung-Hun Han, In Bo Kim, Hyun Sook Kim, Won-Chan Kim, Ok-Joon Kim, Tae Gon Choi, Joong-Uhn Kim, Dong-Seok Kim, Nam Keun |
| description | We conducted a case-control study to investigate whether vascular endothelial growth factor (VEGF -2578, -1154, -634, and 936) and kinase insert domain containing receptor (KDR -604, 1192, and 1719) polymorphisms are associated with moyamoya disease. Korean patients with moyamoya disease (n = 107, mean age, 20.9±15.9 years; 66.4% female) and 243 healthy control subjects (mean age, 23.0±16.1 years; 56.8% female) were included. The subjects were divided into pediatric and adult groups. Among the 64 surgical patients, we evaluated collateral vessel formation after 2 years and divided patients into good (collateral grade A) or poor (collateral grade B and C) groups. The frequencies and distributions of four VEGF (-2578, -1154, -634, and 936) and KDR (-604, 1192, and 1719) polymorphisms were assessed from patients with moyamoya disease and compared to the control group. No differences were observed in VEGF -2578, -1154, -634, and 936 or KDR -604, 1192, and 1719 polymorphisms between the control group and moyamoya disease group. However, we found the -634CC genotype occurred less frequently in the pediatric moyamoya group (p = 0.040) whereas the KDR -604C/1192A/1719T haplotype increased the risk of pediatric moyamoya (p = 0.024). Patients with the CC genotype of VEGF -634 had better collateral vessel formation after surgery. Our results suggest that the VEGF -634G allele is associated with pediatric moyamoya disease and poor collateral vessel formation. |
| doi_str_mv | 10.1371/journal.pone.0047158 |
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Korean patients with moyamoya disease (n = 107, mean age, 20.9±15.9 years; 66.4% female) and 243 healthy control subjects (mean age, 23.0±16.1 years; 56.8% female) were included. The subjects were divided into pediatric and adult groups. Among the 64 surgical patients, we evaluated collateral vessel formation after 2 years and divided patients into good (collateral grade A) or poor (collateral grade B and C) groups. The frequencies and distributions of four VEGF (-2578, -1154, -634, and 936) and KDR (-604, 1192, and 1719) polymorphisms were assessed from patients with moyamoya disease and compared to the control group. No differences were observed in VEGF -2578, -1154, -634, and 936 or KDR -604, 1192, and 1719 polymorphisms between the control group and moyamoya disease group. However, we found the -634CC genotype occurred less frequently in the pediatric moyamoya group (p = 0.040) whereas the KDR -604C/1192A/1719T haplotype increased the risk of pediatric moyamoya (p = 0.024). Patients with the CC genotype of VEGF -634 had better collateral vessel formation after surgery. Our results suggest that the VEGF -634G allele is associated with pediatric moyamoya disease and poor collateral vessel formation.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0047158</identifier><identifier>PMID: 23077562</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Asian Continental Ancestry Group - genetics ; Biology ; Carotid Arteries - metabolism ; Carotid Arteries - physiopathology ; Case-Control Studies ; Child ; Child, Preschool ; Chromosomes ; Disease control ; Female ; Genetic aspects ; Genetic polymorphisms ; Haplotypes ; Humans ; Kinases ; Male ; Medicine ; Moyamoya disease ; Moyamoya Disease - genetics ; Moyamoya Disease - physiopathology ; Neovascularization, Physiologic ; Patients ; Physicians ; Physiological aspects ; Polymorphism, Single Nucleotide ; Quality ; Risk factors ; Rodents ; Surgery ; Vascular endothelial growth factor ; Vascular Endothelial Growth Factor A - genetics ; Vascular Endothelial Growth Factor Receptor-2 - genetics ; Young Adult</subject><ispartof>PloS one, 2012-10, Vol.7 (10), p.e47158-e47158</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>Park et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2012 Park et al 2012 Park et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-1ec1bd39268f05f96cdf44305a06cbfb685d5c442a32fb087c715fe6a0b80ca53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470587/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470587/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23077562$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Arumugam, Thiruma V.</contributor><creatorcontrib>Park, Young Seok</creatorcontrib><creatorcontrib>Jeon, Young Joo</creatorcontrib><creatorcontrib>Kim, Hyun Seok</creatorcontrib><creatorcontrib>Chae, Kyu Young</creatorcontrib><creatorcontrib>Oh, Seung-Hun</creatorcontrib><creatorcontrib>Han, In Bo</creatorcontrib><creatorcontrib>Kim, Hyun Sook</creatorcontrib><creatorcontrib>Kim, Won-Chan</creatorcontrib><creatorcontrib>Kim, Ok-Joon</creatorcontrib><creatorcontrib>Kim, Tae Gon</creatorcontrib><creatorcontrib>Choi, Joong-Uhn</creatorcontrib><creatorcontrib>Kim, Dong-Seok</creatorcontrib><creatorcontrib>Kim, Nam Keun</creatorcontrib><title>The role of VEGF and KDR polymorphisms in moyamoya disease and collateral revascularization</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>We conducted a case-control study to investigate whether vascular endothelial growth factor (VEGF -2578, -1154, -634, and 936) and kinase insert domain containing receptor (KDR -604, 1192, and 1719) polymorphisms are associated with moyamoya disease. Korean patients with moyamoya disease (n = 107, mean age, 20.9±15.9 years; 66.4% female) and 243 healthy control subjects (mean age, 23.0±16.1 years; 56.8% female) were included. The subjects were divided into pediatric and adult groups. Among the 64 surgical patients, we evaluated collateral vessel formation after 2 years and divided patients into good (collateral grade A) or poor (collateral grade B and C) groups. The frequencies and distributions of four VEGF (-2578, -1154, -634, and 936) and KDR (-604, 1192, and 1719) polymorphisms were assessed from patients with moyamoya disease and compared to the control group. No differences were observed in VEGF -2578, -1154, -634, and 936 or KDR -604, 1192, and 1719 polymorphisms between the control group and moyamoya disease group. However, we found the -634CC genotype occurred less frequently in the pediatric moyamoya group (p = 0.040) whereas the KDR -604C/1192A/1719T haplotype increased the risk of pediatric moyamoya (p = 0.024). Patients with the CC genotype of VEGF -634 had better collateral vessel formation after surgery. Our results suggest that the VEGF -634G allele is associated with pediatric moyamoya disease and poor collateral vessel formation.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Biology</subject><subject>Carotid Arteries - metabolism</subject><subject>Carotid Arteries - physiopathology</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Chromosomes</subject><subject>Disease control</subject><subject>Female</subject><subject>Genetic aspects</subject><subject>Genetic polymorphisms</subject><subject>Haplotypes</subject><subject>Humans</subject><subject>Kinases</subject><subject>Male</subject><subject>Medicine</subject><subject>Moyamoya disease</subject><subject>Moyamoya Disease - genetics</subject><subject>Moyamoya Disease - physiopathology</subject><subject>Neovascularization, Physiologic</subject><subject>Patients</subject><subject>Physicians</subject><subject>Physiological aspects</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Quality</subject><subject>Risk factors</subject><subject>Rodents</subject><subject>Surgery</subject><subject>Vascular endothelial growth factor</subject><subject>Vascular Endothelial Growth Factor A - genetics</subject><subject>Vascular Endothelial Growth Factor Receptor-2 - genetics</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk1tv0zAUxyMEYqPwDRBEQkLw0OJL7CQvSNNuVEyaNMZeeLBOHLt15cTFTia6T4-7ZlOD9oAsX2T_zt8-x-ckyVuMZpjm-MvK9b4FO1u7Vs0QynLMimfJIS4pmXKC6PO99UHyKoQVQowWnL9MDghFec44OUx-XS9V6p1VqdPpzen5WQptnX4_uUrXzm4a59dLE5qQmjZt3Aa2Pa1NUBDUPSmdtdApDzb16haC7C14cwedce3r5IUGG9SbYZ4kP89Or4-_TS8uz-fHRxdTmbOim2IlcVXTkvBCI6ZLLmudZRQxQFxWuuIFq5nMMgKU6AoVuYyuasUBVQWSwOgkeb_TXVsXxBCXIDAlnPHI00jMd0TtYCXW3jTgN8KBEfcbzi8E-M5IqwTNNAcdZSuCM0J5mVeaZXHMSQl5RaLW1-G2vmpULVXbRe9HouOT1izFwt1G5Ryx-JpJ8mkQ8O53r0InGhOkinFslevjuzGmZYHKDEf0wz_o094N1AKiA6bVLt4rt6LiKCsLwspIRmr2BBVbrRojYxJpE_dHBp9HBpHp1J9uAX0IYv7j6v_Zy5sx-3GPXSqw3TI4229TJozBbAdK70LwSj8GGSOxrYGHaIhtDYihBqLZu_0PejR6SHr6F5lQATE</recordid><startdate>20121012</startdate><enddate>20121012</enddate><creator>Park, Young Seok</creator><creator>Jeon, Young Joo</creator><creator>Kim, Hyun Seok</creator><creator>Chae, Kyu Young</creator><creator>Oh, Seung-Hun</creator><creator>Han, In Bo</creator><creator>Kim, Hyun Sook</creator><creator>Kim, Won-Chan</creator><creator>Kim, Ok-Joon</creator><creator>Kim, Tae Gon</creator><creator>Choi, Joong-Uhn</creator><creator>Kim, Dong-Seok</creator><creator>Kim, Nam Keun</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20121012</creationdate><title>The role of VEGF and KDR polymorphisms in moyamoya disease and collateral revascularization</title><author>Park, Young Seok ; Jeon, Young Joo ; Kim, Hyun Seok ; Chae, Kyu Young ; Oh, Seung-Hun ; Han, In Bo ; Kim, Hyun Sook ; Kim, Won-Chan ; Kim, Ok-Joon ; Kim, Tae Gon ; Choi, Joong-Uhn ; Kim, Dong-Seok ; Kim, Nam Keun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-1ec1bd39268f05f96cdf44305a06cbfb685d5c442a32fb087c715fe6a0b80ca53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Asian Continental Ancestry Group - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Young Seok</au><au>Jeon, Young Joo</au><au>Kim, Hyun Seok</au><au>Chae, Kyu Young</au><au>Oh, Seung-Hun</au><au>Han, In Bo</au><au>Kim, Hyun Sook</au><au>Kim, Won-Chan</au><au>Kim, Ok-Joon</au><au>Kim, Tae Gon</au><au>Choi, Joong-Uhn</au><au>Kim, Dong-Seok</au><au>Kim, Nam Keun</au><au>Arumugam, Thiruma V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of VEGF and KDR polymorphisms in moyamoya disease and collateral revascularization</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2012-10-12</date><risdate>2012</risdate><volume>7</volume><issue>10</issue><spage>e47158</spage><epage>e47158</epage><pages>e47158-e47158</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>We conducted a case-control study to investigate whether vascular endothelial growth factor (VEGF -2578, -1154, -634, and 936) and kinase insert domain containing receptor (KDR -604, 1192, and 1719) polymorphisms are associated with moyamoya disease. Korean patients with moyamoya disease (n = 107, mean age, 20.9±15.9 years; 66.4% female) and 243 healthy control subjects (mean age, 23.0±16.1 years; 56.8% female) were included. The subjects were divided into pediatric and adult groups. Among the 64 surgical patients, we evaluated collateral vessel formation after 2 years and divided patients into good (collateral grade A) or poor (collateral grade B and C) groups. The frequencies and distributions of four VEGF (-2578, -1154, -634, and 936) and KDR (-604, 1192, and 1719) polymorphisms were assessed from patients with moyamoya disease and compared to the control group. No differences were observed in VEGF -2578, -1154, -634, and 936 or KDR -604, 1192, and 1719 polymorphisms between the control group and moyamoya disease group. However, we found the -634CC genotype occurred less frequently in the pediatric moyamoya group (p = 0.040) whereas the KDR -604C/1192A/1719T haplotype increased the risk of pediatric moyamoya (p = 0.024). Patients with the CC genotype of VEGF -634 had better collateral vessel formation after surgery. Our results suggest that the VEGF -634G allele is associated with pediatric moyamoya disease and poor collateral vessel formation.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23077562</pmid><doi>10.1371/journal.pone.0047158</doi><tpages>e47158</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2012-10, Vol.7 (10), p.e47158-e47158 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1326560873 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adolescent Adult Asian Continental Ancestry Group - genetics Biology Carotid Arteries - metabolism Carotid Arteries - physiopathology Case-Control Studies Child Child, Preschool Chromosomes Disease control Female Genetic aspects Genetic polymorphisms Haplotypes Humans Kinases Male Medicine Moyamoya disease Moyamoya Disease - genetics Moyamoya Disease - physiopathology Neovascularization, Physiologic Patients Physicians Physiological aspects Polymorphism, Single Nucleotide Quality Risk factors Rodents Surgery Vascular endothelial growth factor Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor Receptor-2 - genetics Young Adult |
| title | The role of VEGF and KDR polymorphisms in moyamoya disease and collateral revascularization |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T11%3A30%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20role%20of%20VEGF%20and%20KDR%20polymorphisms%20in%20moyamoya%20disease%20and%20collateral%20revascularization&rft.jtitle=PloS%20one&rft.au=Park,%20Young%20Seok&rft.date=2012-10-12&rft.volume=7&rft.issue=10&rft.spage=e47158&rft.epage=e47158&rft.pages=e47158-e47158&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0047158&rft_dat=%3Cgale_plos_%3EA498259656%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1326560873&rft_id=info:pmid/23077562&rft_galeid=A498259656&rft_doaj_id=oai_doaj_org_article_34f6afca5b21423697bf5497b729a7b2&rfr_iscdi=true |