Phylodynamics and dispersal of HRSV entails its permanence in the general population in between yearly outbreaks in children
Human respiratory syncytial virus (HRSV) is one of the major etiologic agents of respiratory tract infections among children worldwide. Here through a comprehensive analysis of the two major HRSV groups A and B (n=1983) which comprise of several genotypes, we present a complex pattern of population...
Gespeichert in:
| Veröffentlicht in: | PloS one 2012-10, Vol.7 (10), p.e41953-e41953 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e41953 |
|---|---|
| container_issue | 10 |
| container_start_page | e41953 |
| container_title | PloS one |
| container_volume | 7 |
| creator | Katzov-Eckert, Hagit Botosso, Viviane F Neto, Eurico Arruda Zanotto, Paolo Marinho de Andrade |
| description | Human respiratory syncytial virus (HRSV) is one of the major etiologic agents of respiratory tract infections among children worldwide.
Here through a comprehensive analysis of the two major HRSV groups A and B (n=1983) which comprise of several genotypes, we present a complex pattern of population dynamics of HRSV over a time period of 50 years (1956-2006). Circulation pattern of HRSV revealed a series of expansions and fluctuations of co-circulating lineages with a predominance of HRSVA. Positively selected amino acid substitutions of the G glycoprotein occurred upon population growth of GB3 with a 60-nucleotide insertion (GB3 Insert), while other genotypes acquired substitutions upon both population growth and decrease, thus possibly reflecting a role for immune selected epitopes in linkage to the traced substitution sites that may have important relevance for vaccine design. Analysis evidenced the co-circulation and predominance of distinct HRSV genotypes in Brazil and suggested a year-round presence of the virus. In Brazil, GA2 and GA5 were the main culprits of HRSV outbreaks until recently, when the GB3 Insert became highly prevalent. Using Bayesian methods, we determined the dispersal patterns of genotypes through several inferred migratory routes.
Genotypes spread across continents and between neighboring areas. Crucially, genotypes also remained at any given region for extended periods, independent of seasonal outbreaks possibly maintained by re-infecting the general population. |
| doi_str_mv | 10.1371/journal.pone.0041953 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1326560793</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A498259386</galeid><doaj_id>oai_doaj_org_article_e986f2dadf5e474b807b5448c6264ebe</doaj_id><sourcerecordid>A498259386</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-4454e472f3095f1328349093f48c067517121068e0f448f2d1d89cba1dd069d13</originalsourceid><addsrcrecordid>eNqNk8Fu1DAQhiMEoqXwBggiISE47GLHThxfkKoK6EqVilro1XLiycbFa6d2AqzEw-N002qDekA5JPJ888_4z0ySvMRoiQnDH67d4K00y85ZWCJEMc_Jo-QQc5ItigyRx3vfB8mzEK4RyklZFE-Tg4wgxihjh8mfr-3WOLW1cqPrkEqrUqVDBz5Ik7omPb24vErB9lKbkOo-pDG0kRZsDam2ad9CugYLPtKd6wYje-3sGKmg_wVg0y1Ib7apG_rKg_wRxljdaqM82OfJk0aaAC-m91Hy_fOnbyeni7PzL6uT47NFXfCsX1CaU6AsawjieYNJVhLKEScNLWtUsBwznGFUlIAaSssmU1iVvK4kVgoVXGFylLze6XbGBTEZF0RUKvICMU4isdoRyslr0Xm9kX4rnNTi9sD5tZC-17UBAbwsYg2pmjw2RasSsSqPdesiKyhUELU-TtWGagOqju5Fe2ai84jVrVi7n4JQhnnGo8C7ScC7mwFCLzY61GBM9N0NsW-MCWe8vO37zT_ow7ebqLWMF9C2cbFuPYqKY8rLLOdxLiK1fICKj4I4G3HKGh3PZwnvZwmR6eF3v5ZDCGJ1efH_7PnVnH27x7YgTd8GZ4ZxtMIcpDuw9i4ED829yRiJcUnu3BDjkohpSWLaq_0fdJ90txXkL13fDMk</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1326560793</pqid></control><display><type>article</type><title>Phylodynamics and dispersal of HRSV entails its permanence in the general population in between yearly outbreaks in children</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><source>Public Library of Science (PLoS)</source><creator>Katzov-Eckert, Hagit ; Botosso, Viviane F ; Neto, Eurico Arruda ; Zanotto, Paolo Marinho de Andrade</creator><contributor>Planet, Paul J.</contributor><creatorcontrib>Katzov-Eckert, Hagit ; Botosso, Viviane F ; Neto, Eurico Arruda ; Zanotto, Paolo Marinho de Andrade ; VGND consortium ; and the VGND consortium ; Planet, Paul J.</creatorcontrib><description>Human respiratory syncytial virus (HRSV) is one of the major etiologic agents of respiratory tract infections among children worldwide.
Here through a comprehensive analysis of the two major HRSV groups A and B (n=1983) which comprise of several genotypes, we present a complex pattern of population dynamics of HRSV over a time period of 50 years (1956-2006). Circulation pattern of HRSV revealed a series of expansions and fluctuations of co-circulating lineages with a predominance of HRSVA. Positively selected amino acid substitutions of the G glycoprotein occurred upon population growth of GB3 with a 60-nucleotide insertion (GB3 Insert), while other genotypes acquired substitutions upon both population growth and decrease, thus possibly reflecting a role for immune selected epitopes in linkage to the traced substitution sites that may have important relevance for vaccine design. Analysis evidenced the co-circulation and predominance of distinct HRSV genotypes in Brazil and suggested a year-round presence of the virus. In Brazil, GA2 and GA5 were the main culprits of HRSV outbreaks until recently, when the GB3 Insert became highly prevalent. Using Bayesian methods, we determined the dispersal patterns of genotypes through several inferred migratory routes.
Genotypes spread across continents and between neighboring areas. Crucially, genotypes also remained at any given region for extended periods, independent of seasonal outbreaks possibly maintained by re-infecting the general population.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0041953</identifier><identifier>PMID: 23077477</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Amino acids ; Analysis ; Bayesian analysis ; Binding sites ; Bioinformatics ; Biology ; Child ; Child, Preschool ; Children ; Circulation patterns ; Consortia ; Continents ; Disease Outbreaks ; Disease transmission ; Dispersal ; Dispersion ; Epidemiology ; Epitopes ; Etiology ; Evolution ; Genetic aspects ; Genetic diversity ; Genotype ; Genotypes ; Geography ; Glycoproteins ; Humans ; Infant ; Infections ; Influenza ; Insertion ; Laboratories ; Medicine ; Outbreaks ; Population ; Population growth ; Proteins ; Respiratory syncytial virus ; Respiratory syncytial virus infection ; Respiratory Syncytial Virus Infections - epidemiology ; Respiratory Syncytial Virus Infections - virology ; Respiratory Syncytial Viruses - classification ; Respiratory Syncytial Viruses - genetics ; Respiratory tract ; Respiratory tract diseases ; Risk factors ; Virology ; Viruses</subject><ispartof>PloS one, 2012-10, Vol.7 (10), p.e41953-e41953</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>Katzov-Eckert et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2012 Katzov-Eckert et al 2012 Katzov-Eckert et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-4454e472f3095f1328349093f48c067517121068e0f448f2d1d89cba1dd069d13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471929/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471929/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23077477$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Planet, Paul J.</contributor><creatorcontrib>Katzov-Eckert, Hagit</creatorcontrib><creatorcontrib>Botosso, Viviane F</creatorcontrib><creatorcontrib>Neto, Eurico Arruda</creatorcontrib><creatorcontrib>Zanotto, Paolo Marinho de Andrade</creatorcontrib><creatorcontrib>VGND consortium</creatorcontrib><creatorcontrib>and the VGND consortium</creatorcontrib><title>Phylodynamics and dispersal of HRSV entails its permanence in the general population in between yearly outbreaks in children</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Human respiratory syncytial virus (HRSV) is one of the major etiologic agents of respiratory tract infections among children worldwide.
Here through a comprehensive analysis of the two major HRSV groups A and B (n=1983) which comprise of several genotypes, we present a complex pattern of population dynamics of HRSV over a time period of 50 years (1956-2006). Circulation pattern of HRSV revealed a series of expansions and fluctuations of co-circulating lineages with a predominance of HRSVA. Positively selected amino acid substitutions of the G glycoprotein occurred upon population growth of GB3 with a 60-nucleotide insertion (GB3 Insert), while other genotypes acquired substitutions upon both population growth and decrease, thus possibly reflecting a role for immune selected epitopes in linkage to the traced substitution sites that may have important relevance for vaccine design. Analysis evidenced the co-circulation and predominance of distinct HRSV genotypes in Brazil and suggested a year-round presence of the virus. In Brazil, GA2 and GA5 were the main culprits of HRSV outbreaks until recently, when the GB3 Insert became highly prevalent. Using Bayesian methods, we determined the dispersal patterns of genotypes through several inferred migratory routes.
Genotypes spread across continents and between neighboring areas. Crucially, genotypes also remained at any given region for extended periods, independent of seasonal outbreaks possibly maintained by re-infecting the general population.</description><subject>Amino acids</subject><subject>Analysis</subject><subject>Bayesian analysis</subject><subject>Binding sites</subject><subject>Bioinformatics</subject><subject>Biology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Circulation patterns</subject><subject>Consortia</subject><subject>Continents</subject><subject>Disease Outbreaks</subject><subject>Disease transmission</subject><subject>Dispersal</subject><subject>Dispersion</subject><subject>Epidemiology</subject><subject>Epitopes</subject><subject>Etiology</subject><subject>Evolution</subject><subject>Genetic aspects</subject><subject>Genetic diversity</subject><subject>Genotype</subject><subject>Genotypes</subject><subject>Geography</subject><subject>Glycoproteins</subject><subject>Humans</subject><subject>Infant</subject><subject>Infections</subject><subject>Influenza</subject><subject>Insertion</subject><subject>Laboratories</subject><subject>Medicine</subject><subject>Outbreaks</subject><subject>Population</subject><subject>Population growth</subject><subject>Proteins</subject><subject>Respiratory syncytial virus</subject><subject>Respiratory syncytial virus infection</subject><subject>Respiratory Syncytial Virus Infections - epidemiology</subject><subject>Respiratory Syncytial Virus Infections - virology</subject><subject>Respiratory Syncytial Viruses - classification</subject><subject>Respiratory Syncytial Viruses - genetics</subject><subject>Respiratory tract</subject><subject>Respiratory tract diseases</subject><subject>Risk factors</subject><subject>Virology</subject><subject>Viruses</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk8Fu1DAQhiMEoqXwBggiISE47GLHThxfkKoK6EqVilro1XLiycbFa6d2AqzEw-N002qDekA5JPJ888_4z0ySvMRoiQnDH67d4K00y85ZWCJEMc_Jo-QQc5ItigyRx3vfB8mzEK4RyklZFE-Tg4wgxihjh8mfr-3WOLW1cqPrkEqrUqVDBz5Ik7omPb24vErB9lKbkOo-pDG0kRZsDam2ad9CugYLPtKd6wYje-3sGKmg_wVg0y1Ib7apG_rKg_wRxljdaqM82OfJk0aaAC-m91Hy_fOnbyeni7PzL6uT47NFXfCsX1CaU6AsawjieYNJVhLKEScNLWtUsBwznGFUlIAaSssmU1iVvK4kVgoVXGFylLze6XbGBTEZF0RUKvICMU4isdoRyslr0Xm9kX4rnNTi9sD5tZC-17UBAbwsYg2pmjw2RasSsSqPdesiKyhUELU-TtWGagOqju5Fe2ai84jVrVi7n4JQhnnGo8C7ScC7mwFCLzY61GBM9N0NsW-MCWe8vO37zT_ow7ebqLWMF9C2cbFuPYqKY8rLLOdxLiK1fICKj4I4G3HKGh3PZwnvZwmR6eF3v5ZDCGJ1efH_7PnVnH27x7YgTd8GZ4ZxtMIcpDuw9i4ED829yRiJcUnu3BDjkohpSWLaq_0fdJ90txXkL13fDMk</recordid><startdate>20121015</startdate><enddate>20121015</enddate><creator>Katzov-Eckert, Hagit</creator><creator>Botosso, Viviane F</creator><creator>Neto, Eurico Arruda</creator><creator>Zanotto, Paolo Marinho de Andrade</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>COVID</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20121015</creationdate><title>Phylodynamics and dispersal of HRSV entails its permanence in the general population in between yearly outbreaks in children</title><author>Katzov-Eckert, Hagit ; Botosso, Viviane F ; Neto, Eurico Arruda ; Zanotto, Paolo Marinho de Andrade</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-4454e472f3095f1328349093f48c067517121068e0f448f2d1d89cba1dd069d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Amino acids</topic><topic>Analysis</topic><topic>Bayesian analysis</topic><topic>Binding sites</topic><topic>Bioinformatics</topic><topic>Biology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Circulation patterns</topic><topic>Consortia</topic><topic>Continents</topic><topic>Disease Outbreaks</topic><topic>Disease transmission</topic><topic>Dispersal</topic><topic>Dispersion</topic><topic>Epidemiology</topic><topic>Epitopes</topic><topic>Etiology</topic><topic>Evolution</topic><topic>Genetic aspects</topic><topic>Genetic diversity</topic><topic>Genotype</topic><topic>Genotypes</topic><topic>Geography</topic><topic>Glycoproteins</topic><topic>Humans</topic><topic>Infant</topic><topic>Infections</topic><topic>Influenza</topic><topic>Insertion</topic><topic>Laboratories</topic><topic>Medicine</topic><topic>Outbreaks</topic><topic>Population</topic><topic>Population growth</topic><topic>Proteins</topic><topic>Respiratory syncytial virus</topic><topic>Respiratory syncytial virus infection</topic><topic>Respiratory Syncytial Virus Infections - epidemiology</topic><topic>Respiratory Syncytial Virus Infections - virology</topic><topic>Respiratory Syncytial Viruses - classification</topic><topic>Respiratory Syncytial Viruses - genetics</topic><topic>Respiratory tract</topic><topic>Respiratory tract diseases</topic><topic>Risk factors</topic><topic>Virology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Katzov-Eckert, Hagit</creatorcontrib><creatorcontrib>Botosso, Viviane F</creatorcontrib><creatorcontrib>Neto, Eurico Arruda</creatorcontrib><creatorcontrib>Zanotto, Paolo Marinho de Andrade</creatorcontrib><creatorcontrib>VGND consortium</creatorcontrib><creatorcontrib>and the VGND consortium</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Coronavirus Research Database</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Katzov-Eckert, Hagit</au><au>Botosso, Viviane F</au><au>Neto, Eurico Arruda</au><au>Zanotto, Paolo Marinho de Andrade</au><au>Planet, Paul J.</au><aucorp>VGND consortium</aucorp><aucorp>and the VGND consortium</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phylodynamics and dispersal of HRSV entails its permanence in the general population in between yearly outbreaks in children</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2012-10-15</date><risdate>2012</risdate><volume>7</volume><issue>10</issue><spage>e41953</spage><epage>e41953</epage><pages>e41953-e41953</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Human respiratory syncytial virus (HRSV) is one of the major etiologic agents of respiratory tract infections among children worldwide.
Here through a comprehensive analysis of the two major HRSV groups A and B (n=1983) which comprise of several genotypes, we present a complex pattern of population dynamics of HRSV over a time period of 50 years (1956-2006). Circulation pattern of HRSV revealed a series of expansions and fluctuations of co-circulating lineages with a predominance of HRSVA. Positively selected amino acid substitutions of the G glycoprotein occurred upon population growth of GB3 with a 60-nucleotide insertion (GB3 Insert), while other genotypes acquired substitutions upon both population growth and decrease, thus possibly reflecting a role for immune selected epitopes in linkage to the traced substitution sites that may have important relevance for vaccine design. Analysis evidenced the co-circulation and predominance of distinct HRSV genotypes in Brazil and suggested a year-round presence of the virus. In Brazil, GA2 and GA5 were the main culprits of HRSV outbreaks until recently, when the GB3 Insert became highly prevalent. Using Bayesian methods, we determined the dispersal patterns of genotypes through several inferred migratory routes.
Genotypes spread across continents and between neighboring areas. Crucially, genotypes also remained at any given region for extended periods, independent of seasonal outbreaks possibly maintained by re-infecting the general population.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23077477</pmid><doi>10.1371/journal.pone.0041953</doi><tpages>e41953</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2012-10, Vol.7 (10), p.e41953-e41953 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1326560793 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Amino acids Analysis Bayesian analysis Binding sites Bioinformatics Biology Child Child, Preschool Children Circulation patterns Consortia Continents Disease Outbreaks Disease transmission Dispersal Dispersion Epidemiology Epitopes Etiology Evolution Genetic aspects Genetic diversity Genotype Genotypes Geography Glycoproteins Humans Infant Infections Influenza Insertion Laboratories Medicine Outbreaks Population Population growth Proteins Respiratory syncytial virus Respiratory syncytial virus infection Respiratory Syncytial Virus Infections - epidemiology Respiratory Syncytial Virus Infections - virology Respiratory Syncytial Viruses - classification Respiratory Syncytial Viruses - genetics Respiratory tract Respiratory tract diseases Risk factors Virology Viruses |
| title | Phylodynamics and dispersal of HRSV entails its permanence in the general population in between yearly outbreaks in children |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T08%3A59%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Phylodynamics%20and%20dispersal%20of%20HRSV%20entails%20its%20permanence%20in%20the%20general%20population%20in%20between%20yearly%20outbreaks%20in%20children&rft.jtitle=PloS%20one&rft.au=Katzov-Eckert,%20Hagit&rft.aucorp=VGND%20consortium&rft.date=2012-10-15&rft.volume=7&rft.issue=10&rft.spage=e41953&rft.epage=e41953&rft.pages=e41953-e41953&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0041953&rft_dat=%3Cgale_plos_%3EA498259386%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1326560793&rft_id=info:pmid/23077477&rft_galeid=A498259386&rft_doaj_id=oai_doaj_org_article_e986f2dadf5e474b807b5448c6264ebe&rfr_iscdi=true |