Soluble IL-2Rα (sCD25) exacerbates autoimmunity and enhances the development of Th17 responses in mice

A strong association exists between mutations at the IL2 receptor alpha chain (CD25) gene locus and susceptibility to a number of T cell driven autoimmune diseases. Interestingly, the presence of certain CD25 susceptibility alleles has been correlated with significantly increased levels of the solub...

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Veröffentlicht in:	PloS one 2012-10, Vol.7 (10), p.e47748-e47748
Hauptverfasser:	Russell, Shane E, Moore, Anne C, Fallon, Padraic G, Walsh, Patrick T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoimmune diseases Autoimmune Diseases - immunology Autoimmune Diseases - metabolism Autoimmune Diseases - pathology Autoimmunity Biology CD25 antigen Cell Differentiation Cell surface Children & youth Clinical medicine Cytokines Disease Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - metabolism Encephalomyelitis, Autoimmune, Experimental - pathology Experimental allergic encephalomyelitis Helper cells Hospitals Humans Immunity, Cellular Interleukin 2 Interleukin 2 receptors Interleukin-2 - immunology Interleukin-2 - metabolism Interleukin-2 Receptor alpha Subunit - blood Interleukin-2 Receptor alpha Subunit - immunology Lymphocytes Lymphocytes T Medicine Mice Mutation Pathogenesis Proteins R&D Research & development Rheumatoid arthritis Signal Transduction Signaling Th17 Cells - immunology Th17 Cells - metabolism
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