A screen for selective killing of cells with chromosomal instability induced by a spindle checkpoint defect

The spindle assembly checkpoint is crucial for the maintenance of a stable chromosome number. Defects in the checkpoint lead to Chromosomal INstability (CIN), which is linked to the progression of tumors with poor clinical outcomes such as drug resistance and metastasis. As CIN is not found in norma...

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Veröffentlicht in:	PloS one 2012-10, Vol.7 (10), p.e47447-e47447
Hauptverfasser:	Shaukat, Zeeshan, Wong, Heidi W S, Nicolson, Shannon, Saint, Robert B, Gregory, Stephen L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Assembly Biology Cancer Cancer cells Cell Cycle Proteins - genetics Cell Cycle Proteins - isolation & purification Cell Cycle Proteins - metabolism Cell death Cell division Cell growth Cell Survival - genetics Chromosomal Instability - genetics Chromosome number Chromosomes Clinical outcomes Cytoskeleton Cytoskeleton - metabolism Defects Deoxyribonucleic acid DNA Drosophila Drosophila - genetics Drosophila - metabolism Drug resistance Gene Knockdown Techniques Genes Genetic aspects Genetics Genomes Genomic instability Humans Insects JNK protein Kinases M Phase Cell Cycle Checkpoints - genetics MAP Kinase Signaling System Medical prognosis Medicine Metastases Mitosis Molecular Targeted Therapy Mutation NIMA-Related Kinase 1 Phosphatase Phosphoric Monoester Hydrolases - genetics Phosphoric Monoester Hydrolases - metabolism Phosphotransferases - genetics Phosphotransferases - metabolism Physiological aspects Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - isolation & purification Protein-Serine-Threonine Kinases - metabolism Proteins Proteomics RNA interference RNA-mediated interference Signaling Stability Target recognition Therapy Tumorigenesis Tumors
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