Role of Kras status in patients with metastatic colorectal cancer receiving first-line chemotherapy plus bevacizumab: a TTD group cooperative study

In the MACRO study, patients with metastatic colorectal cancer (mCRC) were randomised to first-line treatment with 6 cycles of capecitabine and oxaliplatin (XELOX) plus bevacizumab followed by either single-agent bevacizumab or XELOX plus bevacizumab until disease progression. An additional retrospe...

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Veröffentlicht in:	PloS one 2012-10, Vol.7 (10), p.e47345
Hauptverfasser:	Díaz-Rubio, Eduardo, Gómez-España, Auxiliadora, Massutí, Bartomeu, Sastre, Javier, Reboredo, Margarita, Manzano, José Luis, Rivera, Fernando, Safont, M José, Montagut, Clara, González, Encarnación, Benavides, Manuel, Marcuello, Eugenio, Cervantes, Andrés, Martínez de Prado, Purificación, Fernández-Martos, Carlos, Arrivi, Antonio, Bando, Inmaculada, Aranda, Enrique
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Angiogenesis Antibodies, Monoclonal, Humanized - administration & dosage Antineoplastic Combined Chemotherapy Protocols - therapeutic use Bevacizumab Biology Cancer Cancer metastasis Cancer therapies Capecitabine Care and treatment Chemotherapy Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Data processing Deoxycytidine - administration & dosage Deoxycytidine - analogs & derivatives Dosage and administration Female Fluorouracil - administration & dosage Fluorouracil - analogs & derivatives Genes, ras Genetic aspects Growth factors Health aspects Hospitals Humans Immunotherapy Independent variables K-Ras protein Male Medical prognosis Medicine Metastases Metastasis Middle Aged Monoclonal antibodies Mutation Neoplasm Metastasis Oncology Organoplatinum Compounds - administration & dosage Oxaliplatin Patients Prognosis Reagents Response rates Studies Survival Targeted cancer therapy Tumors
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