Evidence for a developmental role for TLR4 in learning and memory

Toll-like receptors (TLRs) play essential roles in innate immunity and increasing evidence indicates that these receptors are expressed in neurons, astrocytes and microglia in the brain where they mediate responses to infection, stress and injury. Very little is known about the roles of TLRs in cogn...

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Veröffentlicht in:	PloS one 2012-10, Vol.7 (10), p.e47522-e47522
Hauptverfasser:	Okun, Eitan, Barak, Boaz, Saada-Madar, Ravit, Rothman, Sarah M, Griffioen, Kathleen J, Roberts, Nicholas, Castro, Kamilah, Mughal, Mohamed R, Pita, Mario A, Stranahan, Alexis M, Arumugam, Thiruma V, Mattson, Mark P
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analysis of Variance Animals Anxiety Anxiety - metabolism Astrocytes Biology Brain Brain research Cerebral ventricles Cognition Cognitive ability Conditioning (Psychology) - physiology Cyclic AMP response element-binding protein Cyclic AMP Response Element-Binding Protein - metabolism Fear Fear - physiology Gene Expression Regulation - physiology Health aspects Hippocampus Hippocampus - metabolism Hippocampus - physiology Immune system Immunity Immunoblotting Immunological memory Infusions, Intraventricular Innate immunity Laboratories Learning Lipopolysaccharides - administration & dosage Lipopolysaccharides - pharmacology Male Maze Learning - physiology Memory - physiology Mice Mice, Knockout Microglia Motor skill learning Neurons Neurophysiology Neurosciences Physiological aspects Proteins Receptors Rodents Rotarod Performance Test Spatial discrimination learning Spatial memory TLR4 TLR4 protein Toll-Like Receptor 4 - antagonists & inhibitors Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - physiology Toll-like receptors Ventricle (lateral) Ventricles (cerebral)
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