Phase I randomized safety study of twice daily dosing of acidform vaginal gel: candidate antimicrobial contraceptive

Acidform gel, an acid-buffering product that inactivates spermatozoa, may be an effective topical non-hormonal contraceptive. This study was designed to evaluate the safety of vaginal dosing and effects of Acidform on mucosal immune mediators, antimicrobial properties of genital secretions, and vagi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2012-10, Vol.7 (10), p.e46901
Hauptverfasser:	Keller, Marla J, Carpenter, Colleen A, Lo, Yungtai, Einstein, Mark H, Liu, Congzhou, Fredricks, David N, Herold, Betsy C
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Adolescent Adult AIDS Anti-Infective Agents - administration & dosage Anti-Infective Agents - adverse effects Anti-Infective Agents - pharmacology Antiinfectives and antibacterials Antimicrobial activity Bactericidal activity Biology Birth control Buffers Cervix Uteri - drug effects Cervix Uteri - immunology Cervix Uteri - microbiology Chemokines Colonization Cytokines Dosage E coli Epidemiology Female Gynecological Examination HIV Human immunodeficiency virus Humans Hydrogen-Ion Concentration Hydroxyethyl celluloses Immunity Inflammation Inflammation Mediators - metabolism Interleukin 1 Interleukin 1 receptor antagonist Interleukin 1 receptors Interleukins Irritation Lactic Acid - administration & dosage Lactic Acid - adverse effects Lactic Acid - pharmacology Lactoferrin Medication Adherence - statistics & numerical data Medicine Metagenome - drug effects Microbiota Microbiota (Symbiotic organisms) Middle Aged Mucosal immunity pH effects Physicians Proteins Randomization Safety Secretions Spermatocidal Agents - administration & dosage Spermatocidal Agents - adverse effects Spermatocidal Agents - pharmacology Spermatozoa Time Factors Vagina Vagina - drug effects Vagina - immunology Vagina - microbiology Vaginal Creams, Foams, and Jellies Young Adult
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!