Recombinant acylation stimulating protein administration to C3-/- mice increases insulin resistance via adipocyte inflammatory mechanisms

Complement 3 (C3), a key component of the innate immune system, is involved in early inflammatory responses. Acylation stimulating protein (ASP; aka C3adesArg), a C3 cleavage product, is produced in adipose tissue and stimulates lipid storage. We hypothesized that, depending on the diet, chronic ASP...

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Veröffentlicht in:	PloS one 2012-10, Vol.7 (10), p.e46883-e46883
Hauptverfasser:	Munkonda, Mercedes Nancy, Lapointe, Marc, Miegueu, Pierre, Roy, Christian, Gauvreau, Danny, Richard, Denis, Cianflone, Katherine
Format:	Artikel
Sprache:	eng
Schlagworte:	Acylation Adipocytes Adipocytes - drug effects Adipocytes - metabolism Adipose tissue Animals Biology Cardiovascular diseases CCR2 protein CD11c antigen CD36 antigen Complement C3 - deficiency Complement C3 - genetics Complement component C3 Cytokines Diabetes Diabetes mellitus Diet Diet, High-Fat - adverse effects Fatty acids Female Food intake Gene expression Gene Knockout Techniques Granulocyte colony-stimulating factor High fat diet Immune system Inflammation Inflammation - metabolism Inflammation - pathology Inflammatory response Innate immunity Insulin Insulin Resistance Intercellular Signaling Peptides and Proteins - administration & dosage Intercellular Signaling Peptides and Proteins - pharmacology Interleukin 6 JNK protein Kinases Lipid metabolism Lipid Metabolism - drug effects Lipids Low fat Low fat diet Male Medicine Metabolic disorders Metabolic syndrome Metabolism Mice Monocyte chemoattractant protein 1 Muscles Neutrophils NF-κB protein Obesity Proteins RANTES Recombinant Proteins - administration & dosage Recombinant Proteins - pharmacology Rodents Sensitivity Size distribution
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