Role of corticotropin-releasing factor (CRF) receptor-1 on the catecholaminergic response to morphine withdrawal in the nucleus accumbens (NAc)

Stress induces the release of the peptide corticotropin-releasing factor (CRF) into the ventral tegmental area (VTA), and also increases dopamine (DA) levels in brain regions receiving dense VTA input. Since the role of stress in drug addiction is well established, the present study examined the pos...

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Veröffentlicht in:	PloS one 2012-10, Vol.7 (10), p.e47089
Hauptverfasser:	Almela, Pilar, Navarro-Zaragoza, Javier, García-Carmona, Juan-Antonio, Mora, Lucía, Hidalgo, Juana, Milanés, María-Victoria, Laorden, María-Luisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Addictions Adrenocorticotropic hormone Adrenocorticotropin (ACTH) Animals Binding sites Biology Body weight Body weight loss Brain Brain research c-Fos protein Cocaine Corticosterone Corticosterone - blood Corticosterone - metabolism Corticotropin-releasing hormone Dopamine Dopamine - metabolism Dopamine receptors Drug abuse Drug addiction Fos protein Fuel consumption Male Medicine Morphine Morphine - adverse effects Morphine Dependence - metabolism Naloxone Naloxone - pharmacology Neurons Neurons - drug effects Neurons - metabolism Noradrenaline Norepinephrine Norepinephrine - metabolism Nuclei Nucleus accumbens Nucleus Accumbens - drug effects Nucleus Accumbens - metabolism Phosphorylation Phosphorylation - drug effects Pituitary Proteins Proto-Oncogene Proteins c-fos - metabolism Pyrimidines - pharmacology Pyrroles - pharmacology Rats Rats, Sprague-Dawley Receptors Receptors, Corticotropin-Releasing Hormone - antagonists & inhibitors Receptors, Corticotropin-Releasing Hormone - physiology Reinforcement Rodents Serine - metabolism Substance Withdrawal Syndrome - metabolism Tyrosine 3-Monooxygenase - metabolism Ventral Tegmental Area - metabolism Ventral tegmentum Withdrawal
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