DNA polymerase α (swi7) and the flap endonuclease Fen1 (rad2) act together in the S-phase alkylation damage response in S. pombe

Polymerase α is an essential enzyme mainly mediating Okazaki fragment synthesis during lagging strand replication. A specific point mutation in Schizosaccharomyces pombe polymerase α named swi7-1, abolishes imprinting required for mating-type switching. Here we investigate whether this mutation conf...

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Veröffentlicht in:	PloS one 2012-10, Vol.7 (10), p.e47091
Hauptverfasser:	Koulintchenko, Milana, Vengrova, Sonya, Eydmann, Trevor, Arumugam, Prakash, Dalgaard, Jacob Z
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylating Agents - pharmacology Alkylation Biology Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Chemical synthesis Damage detection Deoxyribonucleic acid DNA DNA damage DNA Damage - drug effects DNA Damage - radiation effects DNA polymerase DNA Polymerase I - genetics DNA Polymerase I - metabolism DNA Repair - genetics DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism DNA-directed DNA polymerase Endodeoxyribonucleases - genetics Endodeoxyribonucleases - metabolism Endonuclease FEN1 protein Genomes Genomic imprinting Genomic Instability Hydroxyurea Hydroxyurea - pharmacology Imprinting Intermediates Kinases Mating Methyl Methanesulfonate - pharmacology Mutation Nuclear Proteins - genetics Nuclear Proteins - metabolism Point mutation Recombination Repair S Phase - genetics Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Schizosaccharomyces - cytology Schizosaccharomyces - drug effects Schizosaccharomyces - genetics Schizosaccharomyces - metabolism Schizosaccharomyces pombe Proteins - genetics Schizosaccharomyces pombe Proteins - metabolism Stability Ultraviolet Rays Yeast
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