Efficiency of immunotoxin cytotoxicity is modulated by the intracellular itinerary

Pseudomonas exotoxin-based immunotoxins, including LMB-2 (antiTac(F(v))-PE38), are proposed to traffic to the trans-Golgi network (TGN) and move by a retrograde pathway to the endoplasmic reticulum, where they undergo translocation to the cytoplasm, a step that is essential for cytotoxicity. The ret...

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Veröffentlicht in:	PloS one 2012-10, Vol.7 (10), p.e47320
Hauptverfasser:	Tortorella, Lori L, Pipalia, Nina H, Mukherjee, Sushmita, Pastan, Ira, Fitzgerald, David, Maxfield, Frederick R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - metabolism B cells Biochemistry Biology Biotechnology Cancer CD25 antigen Cell lines Cell Survival - genetics Cell Survival - physiology Chimeras CHO Cells Cricetinae Cytokines Cytoplasm Cytotoxicity Endoplasmic reticulum Endosomes Exotoxins Exotoxins - metabolism Fluorescent Antibody Technique, Indirect Furin Furin - genetics Furin - metabolism Golgi apparatus Humans Immunoblotting Immunotoxins Immunotoxins - genetics Immunotoxins - metabolism Laboratories Medicine Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Membrane proteins Molecular biology Organelles Protein synthesis Proteins Pseudomonas Receptors, Transferrin - genetics Receptors, Transferrin - metabolism Retrograde transport Toxicity Toxins Translocation
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