Ex vivo effect of varespladib on secretory phospholipase A2 alveolar activity in infants with ARDS

Secretory phospholipase A2 (sPLA2) plays a pivotal role in acute respiratory distress syndrome (ARDS). This enzyme seems an interesting target to reduce surfactant catabolism and lung tissue inflammation. Varespladib is a specifically designed indolic sPLA2 inhibitor, which has shown promising resul...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2012-10, Vol.7 (10), p.e47066
Hauptverfasser:	De Luca, Daniele, Minucci, Angelo, Piastra, Marco, Cogo, Paola E, Vendittelli, Francesca, Marzano, Laura, Gentile, Leonarda, Giardina, Bruno, Conti, Giorgio, Capoluongo, Ettore D
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - pharmacology Acute respiratory distress syndrome Adults Alveoli Anesthesiology Babies Biochemistry Biology Bronchoalveolar Lavage Fluid Care and treatment Catabolism Dilution Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Fluid Fluids Gas exchange Health aspects Humans Indoles - pharmacology Infant Infant, Newborn Infants Inflammation Intensive care Isotypes Laboratories Lungs Mechanical ventilation Medicine Molecular biology Neonates Oxygenation Patients Pediatrics Phospholipase Phospholipase A2 Phospholipases Phospholipases A2, Secretory - antagonists & inhibitors Phospholipases A2, Secretory - metabolism Proteins Reduction Respiratory distress syndrome Respiratory Distress Syndrome, Newborn - enzymology Respiratory therapy Surfactants Thoracic surgery Urea Ventilation Ventilators Western blotting
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!