A purpose-synthesised anti-fibrotic agent attenuates experimental kidney diseases in the rat

Locally-active growth factors have been implicated in the pathogenesis of many diseases in which organ fibrosis is a characteristic feature. In the setting of chronic kidney disease (CKD), two such pro-fibrotic factors, transforming growth factor-β (TGF-β) and platelet-derived growth factor (PDGF) h...

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Veröffentlicht in:	PloS one 2012-10, Vol.7 (10), p.e47160
Hauptverfasser:	Gilbert, Richard E, Zhang, Yuan, Williams, Spencer J, Zammit, Steven C, Stapleton, David I, Cox, Alison J, Krum, Henry, Langham, Robyn, Kelly, Darren J
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Albuminuria - complications Albuminuria - drug therapy Animals Biology Blood platelets Caffeic Acids - pharmacology Caffeic Acids - therapeutic use Cell Proliferation - drug effects Cells, Cultured Chronic kidney failure Collagen Collagen - biosynthesis Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - pathology Diabetic nephropathies Diabetic nephropathy Disease Models, Animal Female Fibrosis Growth factors Hospitals Kidney diseases Macrophages - pathology Male Medicine Mesangial Cells - drug effects Nephropathy ortho-Aminobenzoates - pharmacology ortho-Aminobenzoates - therapeutic use Osteopontin - metabolism Pathogenesis Platelet-derived growth factor Platelet-derived growth factor BB Protective Agents - pharmacology Protective Agents - therapeutic use Proteinuria Proto-Oncogene Proteins c-sis - antagonists & inhibitors Rats Rats, Sprague-Dawley Renal Insufficiency, Chronic - drug therapy Renal Insufficiency, Chronic - pathology Rodents Streptozocin Structure-function relationships Studies Transforming growth factor Transforming Growth Factor beta1 - antagonists & inhibitors Transforming growth factors Transplants & implants
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