Bioactive phytochemical proanthocyanidins inhibit growth of head and neck squamous cell carcinoma cells by targeting multiple signaling molecules

Despite advances in surgical and medical therapies, approximate 50% survival rate of head and neck squamous cell carcinoma (HNSCC) has had marginal improvement in the last 30 years. Therefore, alternative strategies are required for the management of HNSCC. Here, we report the chemotherapeutic effec...

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Veröffentlicht in:	PloS one 2012-09, Vol.7 (9), p.e46404-e46404
Hauptverfasser:	Prasad, Ram, Katiyar, Santosh K
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animal models Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis Apoptosis - drug effects BAX protein Bcl-2 protein Binding Biology Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - metabolism Care and treatment Caspase Caspase-3 Cell death Cell Line, Tumor Cell proliferation Cell survival Chemistry Cyclin D1 Cyclin D2 Cyclin-dependent kinase Cyclin-dependent kinase inhibitor p21 Cyclin-Dependent Kinase Inhibitor p21 - genetics Cyclin-Dependent Kinase Inhibitor p21 - metabolism Cyclin-dependent kinase inhibitor p27 Cyclin-Dependent Kinase Inhibitor p27 - genetics Cyclin-Dependent Kinase Inhibitor p27 - metabolism Cyclin-dependent kinases Cyclins Diet Dietary supplements E2F protein Enzyme inhibitors Epidermal growth factor Epidermal growth factor receptors Epidermal growth factors ErbB Receptors - metabolism Head Head & neck cancer Head and neck cancer Head and Neck Neoplasms - drug therapy Head and Neck Neoplasms - metabolism Humans Inhibition Kinases Larynx Medicine Mice Mice, Nude Oral cavity Pharynx Physiological aspects Phytochemicals Prevention Proanthocyanidins Proanthocyanidins - pharmacology Proanthocyanidins - therapeutic use Proteins Rodents Signaling Signaling peptides and proteins Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck Surgery Survival Tongue Tyrosine Xenograft Model Antitumor Assays Xenografts
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